Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.
Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.
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DOI：
10.1016/j.neulet.2013.11.051
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发表时间：
2014-01-24
影响因子：
2.5
通讯作者：
Sivaramakrishnan S
中科院分区：
文献类型：
--
作者：
Grimsley CA;Sivaramakrishnan S
年龄相关性听力损失（AHL）是一种多因素疾病，其特征是外周和中枢听觉功能下降。在这里，我们检查了携带 AHL8 基因的 DBA/2 小鼠在梯形体内侧核 (MNTB) 中可识别的谷氨酸能突触处的突触传递，MNTB 是上橄榄复合体中对声计时至关重要的核。小鼠在听力出现后不久，在 P14 时表现出听觉脑干阈值升高。兴奋性突触后电流延长，但突触后兴奋性正常。到了 P18，高频听力损失就很明显了。与听力损失同时发生，MNTB 主要神经元表现出内在放电特性的变化。这些结果表明，上橄榄复合体传输的变化与早发性听力损失有关。
Age-related hearing loss (AHL) is a multifactorial disorder characterized by a decline in peripheral and central auditory function. Here, we examined synaptic transmission in DBA/2 mice, which carry the AHL8 gene, at the identifiable glutamatergic synapse in the medial nucleus of the trapezoid body (MNTB), a nucleus in the superior olivary complex critical for acoustic timing. Mice exhibited raised auditory brainstem thresholds by P14, soon after hearing onset. Excitatory postsynaptic currents were prolonged, however, postsynaptic excitability was normal. By P18, high-frequency hearing loss was evident. Coincident with the onset of hearing loss, MNTB principal neurons displayed changes in intrinsic firing properties. These results suggest that changes in transmission in the superior olivary complex are associated with early onset hearing loss.
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5.5
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通讯作者：
FORSYTHE, ID
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