Hematological and Pressor Hormone Responses to Mental Stress in Essential Hypertensive Patients: A Comparison with Isometric Handgrip Exercise.
Hematological and Pressor Hormone Responses to Mental Stress in Essential Hypertensive Patients: A Comparison with Isometric Handgrip Exercise.
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原发性高血压患者的血液学和升压激素对精神压力的反应：与等长握力运动的比较。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
J. Fujii
中科院分区：
文献类型：
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作者：
H. Sakamoto;K. Imataka;H. Nishimura;J. Fujii
我们对20例轻度高血压患者进行了精神应激（MS）和等长握力运动（IHG）测试，比较两种测试对血压、心率、血细胞计数和加压激素的反应。质谱法测得的血压和心率增量（平均值±SEM， 42±2/17±1mmHg和8±1beats/mm）与IHG法测得的血压和心率增量（39±3/17±2mmHg和6±1beats/ min）相似。MS试验和IHG试验中，红细胞、白细胞和血小板的堆积体积（分别为1.3±0.3%、1.7±0.3%、10.3±2.1%和2.8±1.6%）和IHG试验（分别为1.3±0.3%、1.0±0.3%、6.2±1.2%和1.9±0.8%）显著增加。在两项试验中，白细胞的百分比增加明显大于红细胞和血小板（p<0.01）。两种试验的比较显示，MS组白细胞计数的增加明显大于IHG组（p <0.05）。血浆去甲肾上腺素、肾上腺素和抗利尿激素水平在两种测试中均显著升高，两种测试中这些加压激素的反应无显著差异。血浆活性肾素和醛固酮水平在MS试验中显著升高，但在IHG试验中保持不变。虽然对两种应激源的反应主要是由交感肾上腺兴奋引起的，但两种测试在细节上存在一些差异。我们得出结论，MS诱导白细胞计数比IHG更大的增加，具有等压反应，并激活肾素-血管紧张素-醛固酮系统，后者没有刺激。（Hypertens Res 1992; 15: 33-39）
We carried out both mental stress (MS) and isometric handgrip exercise (IHG) tests in 20 mild hypertensive patients to compare responses of blood pressure, heart rate, blood cell count and pressor hormones between the two tests. Increments of blood pressure and heart rate by MS (mean±SEM, 42± 2/17±1mmHg and 8±1beats/mm) were similar to those by IHG (39 ±3/17±2mmHg and 6±1beats/ min). Packed cell volume, erythrocytes, leukocytes, and platelets significantly increased in the MS test (1.3±0.3%, 1.7±0.3%, 10.3±2.1% and 2.8±1.6%, respectively) and in the IHG test (1.3±0.3%, 1.0 ±0.3%, 6.2±1.2% and 1.9±0.8% respectively). In both tests the percent increase was significantly greater in leukocytes than in erythrocytes and platelets (p<0.01). A comparison between the two tests revealed that the increase in leukocyte count was significantly greater in the MS than in the IHG test (p <0.05). Plasma noradrenaline, adrenaline and vasopressin levels significantly increased in both tests and there were no significant differences in responses of these pressor hormones between the two tests. Plasma active renin and aldosterone levels significantly increased in the MS test, but remained unchanged in the IHG test. Although the responses to both stressors are mainly induced by the sympathoadrenal excitation, there are some differences in details between the two tests. We concluded that MS induced a greater increase in leukocyte count than IHG with equipressor response and activated the renin-angiotensin-aldosterone system, which was not stimulated by the latter. (Hypertens Res 1992; 15: 33-39)
α1-肾上腺素能刺激循环去甲肾上腺素对血小板、白细胞和红细胞计数的影响。
DOI：
10.1016/0002-9149(89)90096-9
发表时间：
1989
期刊：
The American journal of cardiology
影响因子：
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作者：
Sloand,JA;Hooper,M;IzzoJr,JL
通讯作者：
IzzoJr,JL