What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.
What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.
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DOI：
10.1002/hbm.25098
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发表时间：
2022-01
影响因子：
4.8
通讯作者：
ENIGMA Bipolar Disorder Working Group
中科院分区：
文献类型：
--
作者：
Ching CRK;Hibar DP;Gurholt TP;Nunes A;Thomopoulos SI;Abé C;Agartz I;Brouwer RM;Cannon DM;de Zwarte SMC;Eyler LT;Favre P;Hajek T;Haukvik UK;Houenou J;Landén M;Lett TA;McDonald C;Nabulsi L;Patel Y;Pauling ME;Paus T;Radua J;Soeiro-de-Souza MG;Tronchin G;van Haren NEM;Vieta E;Walter H;Zeng LL;Alda M;Almeida J;Alnaes D;Alonso-Lana S;Altimus C;Bauer M;Baune BT;Bearden CE;Bellani M;Benedetti F;Berk M;Bilderbeck AC;Blumberg HP;Bøen E;Bollettini I;Del Mar Bonnin C;Brambilla P;Canales-Rodríguez EJ;Caseras X;Dandash O;Dannlowski U;Delvecchio G;Díaz-Zuluaga AM;Dima D;Duchesnay É;Elvsåshagen T;Fears SC;Frangou S;Fullerton JM;Glahn DC;Goikolea JM;Green MJ;Grotegerd D;Gruber O;Haarman BCM;Henry C;Howells FM;Ives-Deliperi V;Jansen A;Kircher TTJ;Knöchel C;Kramer B;Lafer B;López-Jaramillo C;Machado-Vieira R;MacIntosh BJ;Melloni EMT;Mitchell PB;Nenadic I;Nery F;Nugent AC;Oertel V;Ophoff RA;Ota M;Overs BJ;Pham DL;Phillips ML;Pineda-Zapata JA;Poletti S;Polosan M;Pomarol-Clotet E;Pouchon A;Quidé Y;Rive MM;Roberts G;Ruhe HG;Salvador R;Sarró S;Satterthwaite TD;Schene AH;Sim K;Soares JC;Stäblein M;Stein DJ;Tamnes CK;Thomaidis GV;Upegui CV;Veltman DJ;Wessa M;Westlye LT;Whalley HC;Wolf DH;Wu MJ;Yatham LN;Zarate CA;Thompson PM;Andreassen OA;ENIGMA Bipolar Disorder Working Group
MRI衍生的大脑测量提供了基因，环境和行为之间的联系，并已在双相情感障碍（BD）中得到广泛研究。然而，许多BD的神经影像学研究动力不足，导致不同的结果和影响的不确定性。通过Meta-分析增强神经成像遗传学（ENIGMA）双相情感障碍工作组成立于2012年，旨在授权发现，产生共识结果并为未来的BD假设驱动研究提供信息。通过这一努力，来自20个国家和55个机构的150多名研究人员汇集了数据和资源，以产生有史以来最大的BD神经影像学研究。ENIGMA双相情感障碍工作组采用标准化的处理和分析技术，为多模态脑MRI的大规模Meta分析和大型分析提供支持，并提高了将大脑变异与临床和遗传数据相关的研究的可重复性。最初的BD工作组研究揭示了与BD相关的较低皮质厚度、皮质下体积和破坏的白色物质完整性的广泛模式。研究结果还包括绘制锂等常见药物的大脑改变，症状模式和临床风险特征，并为BD的病理生理机制提供了进一步的见解。在这里，我们讨论了BD工作组的主要发现，其正在进行的项目以及大规模精神疾病合作研究的未来方向。本综述讨论了双相情感障碍的神经影像学研究所面临的主要挑战，并强调了ENIGMA双相情感障碍工作组的主要成就，持续的挑战和未来的目标。
MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large‐scale meta‐ and mega‐analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large‐scale, collaborative studies of mental illness. This review discusses the major challenges facing neuroimaging research of bipolar disorder and highlights the major accomplishments, ongoing challenges and future goals of the ENIGMA Bipolar Disorder Working Group.
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影响因子：
4.4
作者：
Ekman, Mattias;Granstrom, Ola;Landen, Mikael
通讯作者：
Landen, Mikael
影响因子：
10.6
作者：
de Zwarte, Sonja M. C.;Brouwer, Rachel M.;van Haren, Neeltje E. M.
通讯作者：
van Haren, Neeltje E. M.
DOI：
10.1146/annurev-clinpsy-050212-185608
发表时间：
2013-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9
影响因子：
--
作者：
Borsboom, Denny;Cramer, Angelique O. J.
通讯作者：
Cramer, Angelique O. J.
影响因子：
11
作者：
Farrell, M. S.;Werge, T.;Sklar, P.;Owen, M. J.;Ophoff, R. A.;O'Donovan, M. C.;Corvin, A.;Cichon, S.;Sullivan, P. F.
通讯作者：
Sullivan, P. F.
影响因子：
5.7
作者：
Caspers S;Zilles K;Laird AR;Eickhoff SB
通讯作者：
Eickhoff SB