Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF).
Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF).
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家族性地中海热 (FMF) 环境与遗传背景之间的肠道微生物群。
DOI：
10.3390/genes11091041
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发表时间：
2020-09-03
期刊：
影响因子：
3.5
通讯作者：
Portincasa P
中科院分区：
文献类型：
--
作者：
Di Ciaula A;Stella A;Bonfrate L;Wang DQH;Portincasa P
自出生以来，胃肠道就承载着微生物群的天然储存库。微生物群包括与宿主逐渐建立相互关系的各种细菌。值得注意的是，肠道菌群的组成相当具有个体特异性，通常取决于宿主基因型和环境因素。肠道细菌分布的研究表明，在胃肠道中存在优势门和次要门，细菌密度在口-口方向逐渐增加。肠道内细菌与宿主之间的相互作用对宿主的代谢、结构和保护功能有重要作用。生态失调可在衰老、疾病、炎症状态和抗生素治疗后发生。越来越多的证据表明，微生物群与家族性地中海热（FMF）之间可能存在联系，因为微生物种类的相对丰度发生了变化。在何种程度上，这种微生物群的扰动与驱动FMF的表型表现有关的遗传背景，仍有待进一步研究。
The gastrointestinal tract hosts the natural reservoir of microbiota since birth. The microbiota includes various bacteria that establish a progressively mutual relationship with the host. Of note, the composition of gut microbiota is rather individual-specific and, normally, depends on both the host genotype and environmental factors. The study of the bacterial profile in the gut demonstrates that dominant and minor phyla are present in the gastrointestinal tract with bacterial density gradually increasing in oro-aboral direction. The cross-talk between bacteria and host within the gut strongly contributes to the host metabolism, to structural and protective functions. Dysbiosis can develop following aging, diseases, inflammatory status, and antibiotic therapy. Growing evidences show a possible link between the microbiota and Familial Mediterranean Fever (FMF), through a shift of the relative abundance in microbial species. To which extent such perturbations of the microbiota are relevant in driving the phenotypic manifestations of FMF with respect to genetic background, remains to be further investigated.
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影响因子：
5.5
作者：
Aguilera AC;Dagher IA;Kloepfer KM
通讯作者：
Kloepfer KM
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
168.9
作者：
Ben-Chetrit, E;Levy, M
通讯作者：
Levy, M
影响因子：
5.5
作者：
Accetturo, Matteo;D'Uggento, Angela Maria;Stella, Alessandro
通讯作者：
Stella, Alessandro
影响因子：
5.6
作者：
Balci-Peynircioglu, Banu;Waite, Andrea L.;Gumucio, Deborah L.
通讯作者：
Gumucio, Deborah L.