Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes.
Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes.
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DOI：
10.1093/nar/gkp464
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发表时间：
2009-07
影响因子：
14.9
通讯作者：
Pavesi G
中科院分区：
文献类型：
--
作者：
Zambelli F;Pesole G;Pavesi G
The first step in gene expression, transcription, is modulated by the interaction of transcription factors with their corresponding binding sites on the DNA sequence. Pscan is a software tool that scans a set of sequences (e.g. promoters) from co-regulated or co-expressed genes with motifs describing the binding specificity of known transcription factors and assesses which motifs are significantly over- or under-represented, providing thus hints on which transcription factors could be common regulators of the genes studied, together with the location of their candidate binding sites in the sequences. Pscan does not resort to comparisons with orthologous sequences and experimental results show that it compares favorably to other tools for the same task in terms of false positive predictions and computation time. The website is free and open to all users and there is no login requirement. Address: http://www.beaconlab.it/pscan.
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影响因子：
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14.9
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