Mitochondrial form and function in hair cells.
Mitochondrial form and function in hair cells.
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DOI：
10.1016/j.heares.2022.108660
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发表时间：
2023-02
期刊：
影响因子：
2.8
通讯作者：
Mann, Zoe F.
中科院分区：
文献类型：
--
作者：
O'Sullivan, James D. B.;Bullen, Anwen;Mann, Zoe F.
关键词：
线粒体在听毛细胞的功能和死亡中起重要作用。成像技术的进步揭示了线粒体生物学的新方面。空间和功能离散的线粒体群体支持感觉功能。线粒体结构和功能之间的关系知之甚少。未来的工作应重点关注线粒体-细胞器相互作用的作用。毛细胞（HCs）是位于内耳感觉器官的神经感觉上皮细胞中的专门感觉受体。HC精确的形态和生理特性使我们能够感知声音并与周围的世界互动。线粒体在正常HC功能中起重要作用，并且也复杂地参与HC死亡。它们产生维持离子泵、Ca 2+转运蛋白的活性和转导期间静纤毛束的完整性以及调节突触传递期间细胞溶质钙稳态所必需的ATP。成像技术的进步使我们能够研究整个HC的线粒体群体，以及它们如何与其他细胞器相互作用。这些分析已经确定了不同的线粒体群体之间的顶端和基底外侧部分的HC，其中线粒体形态出现确定的生理过程中的不同的细胞室。对不同物种HC的研究表明，耳毒性物质、衰老和噪音损伤直接影响线粒体结构和功能，导致HC死亡。解密这种线粒体敏感性的分子机制，以及它们的形态如何与HC死亡期间的功能相关，需要我们首先在正常HC功能的背景下理解这种关系。
Mitochondria play a significant role in function and death of auditory hair cells. Advances in imaging have revealed new aspects of mitochondrial biology. Spatially and functionally discrete mitochondrial populations support sensory function. The relationship between mitochondrial structure and function is poorly understood. Future work should focus on the role of mitochondria-organelle interactions. Hair cells (HCs) are specialised sensory receptors residing in the neurosensory epithelia of inner ear sense organs. The precise morphological and physiological properties of HCs allow us to perceive sound and interact with the world around us. Mitochondria play a significant role in normal HC function and are also intricately involved in HC death. They generate ATP essential for sustaining the activity of ion pumps, Ca2+ transporters and the integrity of the stereociliary bundle during transduction as well as regulating cytosolic calcium homoeostasis during synaptic transmission. Advances in imaging techniques have allowed us to study mitochondrial populations throughout the HC, and how they interact with other organelles. These analyses have identified distinct mitochondrial populations between the apical and basolateral portions of the HC, in which mitochondrial morphology appears determined by the physiological processes in the different cellular compartments. Studies in HCs across species show that ototoxic agents, ageing and noise damage directly impact mitochondrial structure and function resulting in HC death. Deciphering the molecular mechanisms underlying this mitochondrial sensitivity, and how their morphology relates to their function during HC death, requires that we first understand this relationship in the context of normal HC function.
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