Overview on poly(ADP-ribose) immuno-biomedicine and future prospects.
Overview on poly(ADP-ribose) immuno-biomedicine and future prospects.
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DOI：
10.2183/pjab.92.222
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kanai Y
中科院分区：
文献类型：
--
作者：
Kanai Y
聚腺苷二磷酸核糖于1966年由斯特拉斯堡、京都和东京三个基团独立鉴定，由聚ADP核糖聚合酶(PARP)以NAD+为底物，在有镁离子存在下合成。它的结构是独特的，因为它具有核糖-核糖键。然而，在20世纪70年代初，它在体内/体外的功能仍然存在争议，需要针对它的抗体来帮助澄清它的意义。于是，作者尝试在兔体内制备抗多聚ADP-核糖的抗体，并在世界上首次获得成功。最终，这一成功导致了以下两篇开创性的论文发表在《自然》杂志上：《自身免疫性疾病系统性红斑狼疮患者中自然产生的针对聚(ADP-核糖)的抗体》和《通过合成双链RNA，聚(A)·聚(U)免疫诱导抗(聚(ADP-核糖)抗体》。在第一篇论文发表的路上，一位评论家友好地对我说，天然抗体的产生有一种“异位”的方式。如上所述，这篇评论对我来说真的是上天赐予的，并成为发表另一篇论文的动力。因此，我认为这一段，我会说，值得在这里描述。由于其在生物医学现象中的重要性，本文将介绍一些与“杂环”有关的文章，尽管它们并不总是与聚腺苷二磷酸核糖的免疫生物学工作直接相关。此外，我还试图推测PARP的产物聚(ADP-核糖)作为一种免疫调节分子的未来前景，包括诱导抗体或自然产生的抗体，鉴于“异质性”。
Poly(ADP-ribose), identified in 1966 independently by three groups Strassbourg, Kyoto and Tokyo, is synthesized by poly(ADP-ribose) polymerases (PARP) from NAD+ as a substrate in the presence of Mg2+. The structure was unique in that it has ribose-ribose linkage. In the early-1970s, however, its function in vivo/in vitro was still controversial and the antibody against it was desired to help clear its significance. Thereupon, the author tried to produce antibody against poly(ADP-ribose) in rabbits and succeeded in it for the first time in the world. Eventually, this success has led to the following two groundbreaking papers in Nature: “Naturally-occurring antibody against poly(ADP-ribose) in patients with autoimmune disease SLE”, and “Induction of anti-poly(ADP-ribose) antibody by immunization with synthetic double-stranded RNA, poly(A)·poly(U)”. On the way to the publication of the first paper, a reviewer gave me a friendly comment that there is “heteroclitic” fashion as a mechanism of the production of natural antibody. This comment was really a God-send for me, and became a train of power for publication of another paper, as described above. Accordingly, I thought this, I would say, episode is worth describing herein. Because of its importance in biomedical phenomena, a certain number of articles related to “heteroclitic” have become to be introduced in this review, although they were not always directly related to immuno-biological works on poly(ADP-ribose). Also, I tried to speculate on the future prospects of poly(ADP-ribose), product of PARP, as an immuno-regulatory molecule, including either induced or naturally-occurring antibodies, in view of “heteroclitic”.
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影响因子：
3.2
作者：
IKAI, K;UEDA, K;HAYAISHI, O
通讯作者：
HAYAISHI, O
DOI：
10.1084/jem.126.1.159
发表时间：
1967-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mäkelä O
通讯作者：
Mäkelä O
影响因子：
56.9
作者：
BRAUN, W;NAKANO, M
通讯作者：
NAKANO, M
影响因子：
4.2
作者：
COSI, C;SUZUKI, H;SKAPER, SD
通讯作者：
SKAPER, SD
影响因子：
3.6
作者：
DELAGE, G;NAHON, E;LACOUR, F
通讯作者：
LACOUR, F