Stromal mediation of radiation carcinogenesis.

Stromal mediation of radiation carcinogenesis.
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DOI:
10.1007/s10911-010-9197-6
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发表时间:
2010-12
影响因子:
2.5
通讯作者:
Barcellos-Hoff MH
Barcellos-Hoff MH
中科院分区:
医学4区
文献类型:
--
作者:
Barcellos-Hoff MH

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Ionizing radiation is a well-established carcinogen in human breast and rodent mammary gland. This review addresses evidence that radiation elicits the critical stromal context for cancer, affecting not only frequency but the type of cancer. Recent data from the breast tumors of women treated with radiation therapy and the cellular mechanisms evident in experimental models suggest that radiation effects on stromal-epithelial interactions and tissue composition are a major determinant of cancer development.
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