Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies.
Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies.
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通过 O-(2-18F-氟乙基)-L-酪氨酸 PET 和扩散加权 MRI 进行胶质瘤成像以及与分子表型的相关性，并通过 PET/MR 引导活检进行验证
DOI：
10.3389/fonc.2021.743655
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发表时间：
2021
影响因子：
4.7
通讯作者：
Lin Q
中科院分区：
文献类型：
--
作者：
Cheng Y;Song S;Wei Y;Xu G;An Y;Ma J;Yang H;Qi Z;Xiao X;Bai J;Xu L;Hu Z;Sun T;Wang L;Lu J;Lin Q
胶质瘤表现出高度的肿瘤内组织学和分子异质性。通过引入立体定向活检，我们使用O-（2- 18 F-氟乙基）-L-酪氨酸（FET）-正电子发射断层扫描（PET）和弥散加权磁共振成像（DWI）对胶质瘤进行了上级分子分析。患者同时接受DWI和FET-PET扫描。确定活检肿瘤组织值（如肿瘤与背景比值（TBR）和表观扩散系数（ADC）/指数ADC（eADC））与组织病理学诊断之间的相关性以及相关基因与TBR和ADC值之间的相关性。端粒酶逆转录酶（hTERT）突变的肿瘤区域TBR较高，ADC值较低。肿瘤蛋白P53突变与低TBR和高ADC值相关。α-地中海贫血/智力低下综合征-X连锁基因（ATRX）与较高的ADC值相关。1 p/19 q共缺失和表皮生长因子受体（EGFR）突变与较低的ADC值相关。异柠檬酸脱氢酶1（IDH 1）突变与较高的TBR平均值相关。TBRmax/TBRmean/ADC/eADC值与磷酸酶和张力蛋白同源物突变（PTEN）或O 6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化之间不存在相关性。此外，TBR/ADC联合诊断高级别和IDH 1、hTERT和EGFR突变胶质瘤的准确性高于每种单一成像方法。本研究首次建立了基于FET-PET和DWI的胶质瘤准确诊断标准。
Gliomas exhibit high intra-tumoral histological and molecular heterogeneity. Introducing stereotactic biopsy, we achieved a superior molecular analysis of glioma using O-(2-18F-fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI). Patients underwent simultaneous DWI and FET-PET scans. Correlations between biopsy-derived tumor tissue values, such as the tumor-to-background ratio (TBR) and apparent diffusion coefficient (ADC)/exponential ADC (eADC) and histopathological diagnoses and those between relevant genes and TBR and ADC values were determined. Tumor regions with human telomerase reverse transcriptase (hTERT) mutation had higher TBR and lower ADC values. Tumor protein P53 mutation correlated with lower TBR and higher ADC values. α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX) correlated with higher ADC values. 1p/19q codeletion and epidermal growth factor receptor (EGFR) mutations correlated with lower ADC values. Isocitrate dehydrogenase 1 (IDH1) mutations correlated with higher TBRmean values. No correlation existed between TBRmax/TBRmean/ADC/eADC values and phosphatase and tensin homolog mutations (PTEN) or O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. Furthermore, TBR/ADC combination had a higher diagnostic accuracy than each single imaging method for high-grade and IDH1-, hTERT-, and EGFR-mutated gliomas. This is the first study establishing the accurate diagnostic criteria for glioma based on FET-PET and DWI.
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DOI：
10.1056/nejmoa1407279
发表时间：
2015-06-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Eckel-Passow JE;Lachance DH;Molinaro AM;Walsh KM;Decker PA;Sicotte H;Pekmezci M;Rice T;Kosel ML;Smirnov IV;Sarkar G;Caron AA;Kollmeyer TM;Praska CE;Chada AR;Halder C;Hansen HM;McCoy LS;Bracci PM;Marshall R;Zheng S;Reis GF;Pico AR;O'Neill BP;Buckner JC;Giannini C;Huse JT;Perry A;Tihan T;Berger MS;Chang SM;Prados MD;Wiemels J;Wiencke JK;Wrensch MR;Jenkins RB
通讯作者：
Jenkins RB
影响因子：
2.4
作者：
Sciortino, Tommaso;Fernandes, Bethania;Riva, Marco
通讯作者：
Riva, Marco
影响因子：
5.8
作者：
Haase S;Garcia-Fabiani MB;Carney S;Altshuler D;Núñez FJ;Méndez FM;Núñez F;Lowenstein PR;Castro MG
通讯作者：
Castro MG
影响因子：
3.9
作者：
Pope, Whitney B.;Qiao, Xin Joe;Kim, Hyun J.;Lai, Albert;Nghiemphu, Phioanh;Xue, Xi;Ellingson, Benjamin M.;Schiff, David;Aregawi, Dawit;Cha, Soonmee;Puduvalli, Vinay K.;Wu, Jing;Yung, Wai-Kwan A.;Young, Geoffrey S.;Vredenburgh, James;Barboriak, Dan;Abrey, Lauren E.;Mikkelsen, Tom;Jain, Rajan;Paleologos, Nina A.;Lada, Patricia;Prados, Michael;Goldin, Jonathan;Wen, Patrick Y.;Cloughesy, Timothy
通讯作者：
Cloughesy, Timothy
影响因子：
2
作者：
Riva, Marco;Lopci, Egesta;Bello, Lorenzo
通讯作者：
Bello, Lorenzo