Aerobic interval training partly reverse contractile dysfunction and impaired Ca2+ handling in atrial myocytes from rats with post infarction heart failure.
Aerobic interval training partly reverse contractile dysfunction and impaired Ca2+ handling in atrial myocytes from rats with post infarction heart failure.
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DOI：
10.1371/journal.pone.0066288
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wisløff U
中科院分区：
文献类型：
--
作者：
Johnsen AB;Høydal M;Røsbjørgen R;Stølen T;Wisløff U
关于衰竭心脏中心房肌细胞Ca 2+处理的知识有限。本研究的目的是检查心肌梗死后心力衰竭（HF）大鼠心房肌细胞收缩功能和Ca 2+处理，并检查有氧间歇训练是否可以逆转潜在的功能障碍。通过结扎冠状动脉左降支在Sprague道利大鼠中诱导梗死后HF。与健康对照组相比，静坐HF大鼠的心房肌细胞缩短被抑制（p <0.01），舒张时间延长（p<0.01）。这与Ca 2+振幅降低、SR Ca 2+含量降低和Ca 2+瞬时衰减较慢有关。HF大鼠心房肌细胞肌浆网Ca ~（2+）ATP酶活性降低，Na ~+/Ca ~（2+）交换活性增加，舒张期Ca ~（2+）通过Ryanodine受体漏出增加。HF大鼠高强度有氧间歇训练恢复了心房肌细胞收缩功能，逆转了HF大鼠心房Ca 2+处理的变化。大鼠梗死后HF导致心房肌细胞收缩功能和Ca 2+处理严重受损。有氧间歇训练可部分逆转心房肌细胞的功能障碍。
There is limited knowledge about atrial myocyte Ca2+ handling in the failing hearts. The aim of this study was to examine atrial myocyte contractile function and Ca2+ handling in rats with post-infarction heart failure (HF) and to examine whether aerobic interval training could reverse a potential dysfunction. Post-infarction HF was induced in Sprague Dawley rats by ligation of the left descending coronary artery. Atrial myocyte shortening was depressed (p<0.01) and time to relaxation was prolonged (p<0.01) in sedentary HF-rats compared to healthy controls. This was associated with decreased Ca2+ amplitude, decreased SR Ca2+ content, and slower Ca2+ transient decay. Atrial myocytes from HF-rats had reduced sarcoplasmic reticulum Ca2+ ATPase activity, increased Na+/Ca2+-exchanger activity and increased diastolic Ca2+ leak through ryanodine receptors. High intensity aerobic interval training in HF-rats restored atrial myocyte contractile function and reversed changes in atrial Ca2+ handling in HF. Post infarction HF in rats causes profound impairment in atrial myocyte contractile function and Ca2+ handling. The observed dysfunction in atrial myocytes was partly reversed after aerobic interval training.
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