Orderly recruitment of motor units under optical control in vivo.
Orderly recruitment of motor units under optical control in vivo.
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DOI：
10.1038/nm.2228
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发表时间：
2010-10
期刊：
影响因子：
82.9
通讯作者：
Delp SL
中科院分区：
文献类型：
--
作者：
Llewellyn ME;Thompson KR;Deisseroth K;Delp SL
用于肌肉控制的电刺激的缺点在于，通过最低强度的电袖带刺激，大的易疲劳的运动单元优先在较小的运动单元之前被募集。这种现象限制了治疗应用，因为它正好与正常的生理（有序）募集模式相反;因此，实现有序募集的机制一直是生理学、医学和工程学中长期寻求的目标。在这里，我们展示了一种可靠的有序招募体内的技术。我们发现，在微生物视蛋白的光学控制下，运动单位的募集在生理募集序列中进行，如运动单位募集的多个独立测量所示，包括传导潜伏期、收缩和松弛时间、刺激阈值和疲劳。因此，我们观察到增强的性能和减少体内疲劳。这些发现指出了一种意想不到的神经控制新模式，对神经系统和神经肌肉生理学，疾病研究和治疗创新具有广泛的影响。
A drawback of electrical stimulation for muscle control is that large, fatigable motor units are preferentially recruited before smaller motor units by the lowest-intensity electrical cuff stimulation. This phenomenon limits therapeutic applications because it is precisely the opposite of the normal physiological (orderly) recruitment pattern; therefore, a mechanism to achieve orderly recruitment has been a long-sought goal in physiology, medicine and engineering. Here we demonstrate a technology for reliable orderly recruitment in vivo. We find that under optical control with microbial opsins, recruitment of motor units proceeds in the physiological recruitment sequence, as indicated by multiple independent measures of motor unit recruitment including conduction latency, contraction and relaxation times, stimulation threshold and fatigue. As a result, we observed enhanced performance and reduced fatigue in vivo. These findings point to an unanticipated new modality of neural control with broad implications for nervous system and neuromuscular physiology, disease research and therapeutic innovation.
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