Sensory and sympathetic nervous system control of white adipose tissue lipolysis.
Sensory and sympathetic nervous system control of white adipose tissue lipolysis.
复制标题
DOI：
10.1016/j.mce.2009.08.031
复制
发表时间：
2010-04-29
影响因子：
4.1
通讯作者：
Song, C. K.
中科院分区：
文献类型：
--
作者：
Bartness, Timothy J.;Shrestha, Y. B.;Vaughan, C. H.;Schwartz, G. J.;Song, C. K.
循环因素通常被用来解释中枢神经系统和白色脂肪组织（WAT）之间的双向通讯。因此，脂解的启动主要归因于肾上腺髓质分泌的儿茶酚胺，脂解的抑制主要归因于胰腺胰岛素，而体脂肪水平向大脑的信号归因于脂肪因子如瘦素。相比之下，证据是大脑和WAT之间的双向通信发生通过交感神经系统（SNS）和感觉神经支配的这个组织。使用逆行跨神经元病毒道示踪剂，SNS流出从大脑到WAT已被定义。在功能上，交感神经的WAT块脂肪分解各种脂解刺激。使用顺行跨神经元病毒道示踪剂，从WAT到大脑的感觉输入已被定义。在功能上，这些WAT感觉神经对WAT SNS驱动的增加作出电生理反应，这表明可能存在调节脂解的神经负反馈回路。
Circulating factors are typically invoked to explain bidirectional communication between the CNS and white adipose tissue (WAT). Thus, initiation of lipolysis has been relegated primarily to adrenal medullary secreted catecholamines and the inhibition of lipolysis primarily to pancreatic insulin, whereas signals of body fat levels to the brain have been ascribed to adipokines such as leptin. By contrast, evidence is given for bidirectional communication between brain and WAT occurring via the sympathetic nervous system (SNS) and sensory innervation of this tissue. Using retrograde transneuronal viral tract tracers, the SNS outflow from brain to WAT has been defined. Functionally, sympathetic denervation of WAT blocks lipolysis to a variety of lipolytic stimuli. Using anterograde transneuronal viral tract tracers, the sensory input from WAT to brain has been defined. Functionally, these WAT sensory nerves respond electrophysiologically to increases in WAT SNS drive suggesting a possible neural negative feedback loop to regulate lipolysis.
登录
查看更多内容
影响因子：
3.1
作者：
BALLARD, K;MALMFORS, T;ROSELL, S
通讯作者：
ROSELL, S
影响因子：
2.9
作者：
Bartness, TJ
通讯作者：
Bartness, TJ
影响因子：
4.8
作者：
Brito, Marcia N.;Brito, Nilton A.;Bartness, Timothy J.
通讯作者：
Bartness, Timothy J.
DOI：
10.1016/0165-1838(93)90046-w
发表时间：
1993-02-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
BERTHOUD, HR;POWLEY, TL
通讯作者：
POWLEY, TL
DOI：
10.1152/ajpregu.00792.2004
发表时间：
2005-05-01
影响因子：
2.8
作者：
Bowers, RR;Gettys, TW;Bartness, TJ
通讯作者：
Bartness, TJ