Activation for newly learned words in left medial-temporal lobe during toddlers' sleep is associated with memory for words.
Activation for newly learned words in left medial-temporal lobe during toddlers' sleep is associated with memory for words.
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DOI：
10.1016/j.cub.2021.09.058
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发表时间：
2021-12-20
期刊：
影响因子：
--
通讯作者：
Ghetti S
中科院分区：
文献类型：
--
作者：
Johnson EG;Mooney L;Graf Estes K;Nordahl CW;Ghetti S
关于早期记忆功能的神经基质知之甚少。为了获得更多的洞察力，我们研究了幼儿如何记住新学的单词。海马和前内侧颞叶（MTL）的过程已被假设为支持形成和保持之间的联系，新的单词和他们的参考，但在幼儿期这种联系的直接证据是缺乏的。我们评估了2岁儿童（N = 38）的记忆新学到的假词与新的物体和木偶。我们在学习的同一阶段和延迟一周后测试了这些关联的记忆。然后，我们在自然夜间睡眠中播放这些伪词，以前已知的词，以及完全新的伪词，同时收集功能性磁共振成像数据。激活左侧海马和左前MTL的新学到的新单词相比，与相同的会话记忆这些新学到的单词，只有当他们被学习的木偶名字。在一周的延迟中，已知单词的激活与木偶名字的记忆有关。对新学单词的激活也与整体产出性词汇相关。这些结果强调了记忆机制和内侧颞叶单词学习之间的早期发展联系。约翰逊等人通过评估幼儿睡眠时与这些单词相关的神经激活来研究幼儿如何记住新学的单词。海马和前内侧颞叶对新学单词的激活与对这些单词的记忆有关，强调了记忆和早期单词学习之间的联系。
Little is known about the neural substrates underlying early memory functioning. In order to gain more insight, we examined how toddlers remember newly learned words. Hippocampal and anterior medial-temporal lobe (MTL) processes have been hypothesized to support forming and retaining the association between novel words and their referents, but direct evidence of this connection in early childhood is lacking. We assessed 2-year-olds (N = 38) for their memory of newly learned pseudowords associated with novel objects and puppets. We tested memory for these associations during the same session as learning and after a one-week delay. We then played these pseudowords, previously known words, and completely novel pseudowords during natural nocturnal sleep, while collecting functional magnetic resonance imaging data. Activation in left hippocampus and left anterior MTL for newly learned compared to novel words was associated with same-session memory for these newly learned words only when they were learned as puppet names. Activation for known words was associated with memory for puppet names at the one-week delay. Activation for newly learned words was also associated with overall productive vocabulary. These results underscore an early developing link between memory mechanisms and word learning in the medial temporal lobe. Johnson et al. examine how toddlers remember newly learned words by assessing neural activation associated with these words while toddlers are asleep. Hippocampal and anterior medial temporal lobe activation for newly learned words is associated with memory for these words, underscoring a link between memory and word learning in early life.
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DOI：
10.1098/rstb.2009.0111
发表时间：
2009-12-27
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Davis MH;Gaskell MG
通讯作者：
Gaskell MG
DOI：
10.1073/pnas.0606302103
发表时间：
2006-09-19
影响因子：
11.1
作者：
Dehaene-Lambertz, Ghislaine;Hertz-Pannier, Lucie;Dehaene, Stanislas
通讯作者：
Dehaene, Stanislas
影响因子：
2.1
作者：
Fenson, L;Pethick, S;Reznick, JS
通讯作者：
Reznick, JS
影响因子：
5.7
作者：
Bellander, Martin;Berggren, Rasmus;Lovden, Martin
通讯作者：
Lovden, Martin
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y