Therapeutic effects of antimicrobial peptide on malignant ascites in a mouse model.
Therapeutic effects of antimicrobial peptide on malignant ascites in a mouse model.
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抗菌肽对小鼠恶性腹水模型的治疗作用
DOI：
10.3892/mmr.2018.8691
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发表时间：
2018-05
影响因子：
3.4
通讯作者：
Zhang FC
中科院分区：
文献类型：
--
作者：
Xia LJ;Wu YL;Ma J;Zhang FC
治疗晚期恶性腹水的主要目的是通过利尿、视网膜下液穿刺和腔静脉吻合术来缓解症状。全身或腹腔化疗治疗的有效性有限，需要更有效的治疗。本研究的作者证明了从家蚕幼虫中分离的抗菌肽cecropinXJ选择性地抑制胃癌细胞的增殖。然而，抗菌肽对胃腹水肿瘤的作用尚不清楚。本研究观察了抗菌肽XJ对小鼠恶性腹水的治疗作用。与牛血清白蛋白组相比，抗菌肽XJ和阿霉素（Dox）能显著抑制恶性腹水的形成和生长，延长腹水荷瘤小鼠的生存时间。此外，与Dox治疗相比，天蚕抗菌肽XJ治疗使血液学和生化表型正常化，诱导腹水中的肿瘤细胞凋亡，并提高了携带恶性腹水的小鼠的存活率。这些结果表明，抗菌肽XJ可能是一个有前途的治疗胃癌相关腹水的候选药物。
The primary objective of the treatment of malignant ascites in advanced stages is to alleviate symptoms using procedures such as diuresis, paracentesis of subretinal fluid and vena cava anastomosis. The effectiveness of systemic or intraperitoneal chemotherapy treatment is limited, and more efficacious therapies are required. The authors of the present study demonstrated that an antimicrobial peptide, cecropinXJ, isolated from the larvae of Bombyx mori, selectively inhibits the proliferation of gastric cancer cells. However, the effects of antibacterial peptides on gastric ascites tumor remains unclear. In the present study, the therapeutic effects of cecropinXJ were investigated in mice bearing malignant ascites. Compared with bovine serum albumin treatment, cecropinXJ and doxorubicin (Dox) significantly inhibited the formation and growth of malignant ascites, and prolonged the survival time of ascites tumor-bearing mice. In addition, cecropinXJ treatment normalized the hematological and biochemical phenotypes, induced tumor cell apoptosis in ascites and improved the survival of mice bearing malignant ascites when compared with Dox treatment. These results suggested that cecropinXJ might be a promising therapeutic candidate for the treatment of gastric cancer-associated ascites.
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影响因子：
5.2
作者：
Wu, Yan-Ling;Xia, Li-Jie;Zhang, Fu-Chun
通讯作者：
Zhang, Fu-Chun
影响因子：
3.7
作者：
Xia, Lijie;Wu, Yanling;Zhang, Fuchun
通讯作者：
Zhang, Fuchun
DOI：
10.1073/pnas.88.9.3792
发表时间：
1991-05-01
影响因子：
11.1
作者：
CRUCIANI, RA;BARKER, JL;COLAMONICI, O
通讯作者：
COLAMONICI, O
影响因子：
1.6
作者：
Xia, Lijie;Liu, Zhongyuan;Zhang, Fuchun
通讯作者：
Zhang, Fuchun
影响因子：
--
作者：
Zolfagharzadeh, Fatemeh;Roshan, Valiollah Dabidi
通讯作者：
Roshan, Valiollah Dabidi