Selection of and evasion from cytotoxic T cell responses in the central nervous system.
Selection of and evasion from cytotoxic T cell responses in the central nervous system.
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DOI：
10.1016/s0065-3527(01)56029-7
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发表时间：
2001
影响因子：
--
通讯作者：
Wu GF
中科院分区：
文献类型：
--
作者：
Perlman S;Wu GF
细胞毒性CD8 T淋巴细胞（ctl）对于清除感染细胞中的非细胞病变病毒至关重要。本章讨论了病毒持续存在的一种机制，即选择一种变异病毒，其中CTL表位序列的变化取消了识别。本文讨论了细胞毒性CD8 T细胞在中枢神经系统（CNS）中的独特功能。综述了非中枢神经系统感染中CTL逃逸突变体在病毒逃避免疫系统和随后疾病进展中的作用。中枢神经系统的免疫反应与神经外组织的免疫反应相似，但免疫反应的激活、细胞运输和抗原呈递的几个方面是中枢神经系统所独有的。尽管传统上认为中枢神经系统是免疫特权的一个部位，但正常中枢神经系统的监视是通过循环激活的淋巴细胞进行的，在任何给定时间，正常中枢神经系统中存在有限数量的淋巴细胞。在感染小鼠肝炎病毒的小鼠和一些持续感染人类免疫缺陷病毒1型、乙型肝炎病毒或丙型肝炎病毒的人类中，CTL逃逸突变体在病毒扩增和疾病进展中起重要作用。
Cytotoxic CD8 T lymphocytes (CTLs) are critical for the clearance of noncytopathic viruses from infected cells. This chapter discusses one mechanism used by viruses to persist—namely, the selection of a variant virus in which changes in the sequence of a CTL epitope abrogate recognition. The unique features of cytotoxic CD8 T cell function in the central nervous system (CNS) are discussed. The role of CTL escape mutants in the viral evasion of the immune system and subsequent disease progression in non-CNS infections are summarized. The immune response in the CNS is similar to the response in extraneural tissue, but several aspects of the activation of the immune response, cellular trafficking, and antigen presentation are unique to the CNS. Although the CNS has classically been considered a site of immune privilege, surveillance of the normal CNS by circulating, activated lymphocytes occurs, with a limited number of lymphocytes being present in the normal CNS at any given time. In mice infected with mouse hepatitis virus and in some humans persistently infected with human immunodeficiency virus type1, hepatitis B virus or hepatitis C virus, CTL escape mutants play an important role in virus amplification and disease progression.
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影响因子：
4.8
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影响因子：
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