Acanthamoeba and Dictyostelium Use Different Foraging Strategies.
Acanthamoeba and Dictyostelium Use Different Foraging Strategies.
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Acanthamoeba和Dictyostelium使用不同的觅食策略。
DOI：
10.1016/j.protis.2016.08.006
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发表时间：
2016-12
期刊：
影响因子：
2.5
通讯作者：
Hadwiger, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Kuburich, Nick A.;Adhikari, Nirakar;Hadwiger, Jeffrey A.
阿米巴经常利用细胞运动作为在其环境中寻找食物（例如细菌）的机制。土壤变形虫Dictyosteelium对细菌释放的叶酸或其他蝶呤化合物的趋化运动是一种有据可查的觅食机制。变形虫也可以以细菌为食，但对这种变形虫定位细菌的机制知之甚少。在上述琼脂测定中分析了在叶酸盐或细菌存在下的阿米巴移动，并与对网骨藻观察到的移动进行了比较。阿米巴的整体流动性是强大的，像网骨藻，但阿米巴没有显示出对叶酸的趋化反应。在细菌的存在下，阿米巴只表现出边缘偏向定向运动，而Dictyosteoprotein表现出强烈的趋化反应。基因组的比较显示，阿米巴和网骨藻在G蛋白信号传导组分方面有一些相似之处，但在目前的阿米巴基因组序列数据中不存在用于网骨藻趋化反应的特定G蛋白。这项研究的结果表明，阿米巴不使用趋化性作为主要的机制，以找到细菌的食物来源，和Dictyostelium的趋化反应，细菌可能已经共同进化的趋化反应，促进多细胞的发展。
Amoeba often use cell movement as a mechanism to find food, such as bacteria, in their environment. The chemotactic movement of the soil amoeba Dictyostelium to folate or other pterin compounds released by bacteria is a well-documented foraging mechanism. Acanthamoeba can also feed on bacteria but relatively little is known about the mechanism(s) by which this amoeba locates bacteria. Acanthamoeba movement in the presence of folate or bacteria was analyzed in above agar assays and compared to that observed for Dictyostelium. The overall mobility of Acanthamoeba was robust like that of Dictyostelium but Acanthamoeba did not display a chemotactic response to folate. In the presence of bacteria, Acanthamoeba only showed a marginal bias in directed movement whereas Dictyostelium displayed a strong chemotactic response. A comparison of genomes revealed that Acanthamoeba and Dictyostelium share some similarities in G protein signaling components but that specific G proteins used in Dictyostelium chemotactic responses were not present in current Acanthamoeba genome sequence data. The results of this study suggest that Acanthamoeba does not use chemotaxis as the primary mechanism to find bacterial food sources and that the chemotactic responses of Dictyostelium to bacteria may have co-evolved with chemotactic responses that facilitate multicellular development.
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DOI：
10.1093/bioinformatics/8.3.275
发表时间：
1992-06-01
期刊：
COMPUTER APPLICATIONS IN THE BIOSCIENCES
影响因子：
--
作者：
JONES, DT;TAYLOR, WR;THORNTON, JM
通讯作者：
THORNTON, JM
影响因子：
8
作者：
Artemenko, Yulia;Lampert, Thomas J.;Devreotes, Peter N.
通讯作者：
Devreotes, Peter N.
DOI：
10.1016/0167-4889(86)90214-4
发表时间：
1986-04-08
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
DEWIT, RJW;BULGAKOV, R
通讯作者：
BULGAKOV, R
影响因子：
4.6
作者：
Anjard, Christophe;Su, Yongxuan;Loomis, William F.
通讯作者：
Loomis, William F.
影响因子：
10.7
作者：
Kumar, Sudhir;Stecher, Glen;Tamura, Koichiro
通讯作者：
Tamura, Koichiro