Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
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DOI：
10.1038/nn.3141
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发表时间：
2012-06-10
影响因子：
25
通讯作者：
Tsai, Li-Huei
中科院分区：
文献类型：
--
作者：
de Anda, Froylan Calderon;Rosario, Ana Lucia;Durak, Omer;Tran, Tracy;Graeff, Johannes;Meletis, Konstantinos;Rei, Damien;Soda, Takahiro;Madabhushi, Ram;Ginty, David D.;Kolodkin, Alex L.;Tsai, Li-Huei
神经元如何发育其形态是神经生物学中的一个重要问题。在这里，我们描述了一种新的途径，具体影响皮层锥体神经元的基底树突和轴突投射的形成。我们报告，一千零一氨基酸2（TAO 2）激酶在树突形态发生中起着至关重要的作用。TAO 2下调损害体内基底树突形成，而不影响顶端树突。此外，TAO 2与神经纤毛蛋白1（Npn 1）相互作用，神经纤毛蛋白1是一种结合分泌的导向因子脑信号蛋白3A（Sema 3A）的受体蛋白。TAO 2过表达恢复了Npn 1 Sema −小鼠培养的皮层神经元中的树突形成，这些神经元表达不能结合Sema 3A的Npn 1受体。TAO 2过表达也改善了由体内Npn 1下调引起的基底树突损伤。最后，Sema 3A和TAO 2通过激活c-Jun N-末端激酶（JNK）调节基底树突的形成。这些结果描绘了一个途径，Sema 3A和Npn 1 β信号通过TAO 2和JNK调节皮质神经元的基底树突发育。
How neurons develop their morphology is an important question in neurobiology. Here we describe a novel pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 (TAO2) kinase plays an essential role in dendrite morphogenesis. TAO2 down-regulation impairs basal dendrite formation in vivo without affecting apical dendrites. Moreover, TAO2 interacts with Neuropilin 1 (Npn1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAO2 over-expression restores dendrite formation in cultured cortical neurons from Npn1Sema− mice, which express Npn1 receptors incapable of binding Sema3A. TAO2 over-expression also ameliorates the basal dendrite impairment resulting from Npn1 down-regulation in vivo. Finally, Sema3A and TAO2 modulate the formation of basal dendrites through the activation of the c-Jun N-Terminal Kinase (JNK). These results delineate a pathway whereby Sema3A and Npn1 transduce signals through TAO2 and JNK to regulate basal dendrite development in cortical neurons.
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影响因子：
30.8
作者：
McCarthy, Shane E.;Makarov, Vladimir;Kirov, George;Addington, Anjene M.;McClellan, Jon;Yoon, Seungtai;Perkins, Diana O.;Dickel, Diane E.;Kusenda, Mary;Krastoshevsky, Olga;Krause, Verena;Kumar, Ravinesh A.;Grozeva, Detelina;Malhotra, Dheeraj;Walsh, Tom;Zackai, Elaine H.;Kaplan, Paige;Ganesh, Jaya;Krantz, Ian D.;Spinner, Nancy B.;Roccanova, Patricia;Bhandari, Abhishek;Pavon, Kevin;Lakshmi, B.;Leotta, Anthony;Kendall, Jude;Lee, Yoon-ha;Vacic, Vladimir;Gary, Sydney;Iakoucheva, Lilia M.;Crow, Timothy J.;Christian, Susan L.;Lieberman, Jeffrey A.;Stroup, T. Scott;Lehtimaki, Terho;Puura, Kaija;Haldeman-Englert, Chad;Pearl, Justin;Goodell, Meredith;Willour, Virginia L.;DeRosse, Pamela;Steele, Jo;Kassem, Layla;Wolff, Jessica;Chitkara, Nisha;McMahon, Francis J.;Malhotra, Anil K.;Potash, James B.;Schulze, Thomas G.;Noethen, Markus M.;Cichon, Sven;Rietschel, Marcella;Leibenluft, Ellen;Kustanovich, Vlad;Lajonchere, Clara M.;Sutcliffe, James S.;Skuse, David;Gill, Michael;Gallagher, Louise;Mendell, Nancy R.;Craddock, Nick;Owen, Michael J.;O'Donovan, Michael C.;Shaikh, Tamim H.;Susser, Ezra;DeLisi, Lynn E.;Sullivan, Patrick F.;Deutsch, Curtis K.;Rapoport, Judith;Levy, Deborah L.;King, Mary-Claire;Sebat, Jonathan
通讯作者：
Sebat, Jonathan
影响因子：
16.2
作者：
Horton, AC;Rácz, B;Ehlers, MD
通讯作者：
Ehlers, MD
影响因子：
5.3
作者：
Björkblom, B;Östman, N;Coffey, ET
通讯作者：
Coffey, ET
影响因子：
4.7
作者：
Ben-Zvi, A;Yagil, Z;Behar, O
通讯作者：
Behar, O
DOI：
10.1083/jcb.109.6.3085
发表时间：
1989-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Baas PW;Black MM;Banker GA
通讯作者：
Banker GA