The average body surface area of adult cancer patients in the UK: a multicentre retrospective study.
The average body surface area of adult cancer patients in the UK: a multicentre retrospective study.
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DOI：
10.1371/journal.pone.0008933
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发表时间：
2010-01-28
期刊：
影响因子：
3.7
通讯作者：
Clark P
中科院分区：
文献类型：
--
作者：
Sacco JJ;Botten J;Macbeth F;Bagust A;Clark P
大多数化疗药物是根据体表面积(BSA)给药的。在英国接受治疗的患者没有标准的BSA值可用来计算剂量和成本。因此，我们回顾评估了2005年1月1日至2005年12月31日期间在英国三个肿瘤学中心接受化疗的患者的BSA。共有3613名头颈部、卵巢癌、肺癌、上消化道/胰腺癌、乳腺癌或结直肠癌患者接受化疗。总体平均BSA为1.79m2(95%可信区间1.78~1.80)，其中男性为1.91m2(1.90~1.92)，女性为1.71m2(1.70~1.72)。三个中心的结果是一致的。乳腺癌或结直肠癌患者的辅助治疗和姑息治疗之间没有显著差异。然而，在一些肿瘤组之间检测到了统计上显著的差异，尽管差异很小。鉴于三个不同地理位置的英国癌症中心的结果是一致的，我们相信这项研究的结果可能会被推广并用于未来英国新化疗药物的成本和预算。
The majority of chemotherapy drugs are dosed based on body surface area (BSA). No standard BSA values for patients being treated in the United Kingdom are available on which to base dose and cost calculations. We therefore retrospectively assessed the BSA of patients receiving chemotherapy treatment at three oncology centres in the UK between 1st January 2005 and 31st December 2005. A total of 3613 patients receiving chemotherapy for head and neck, ovarian, lung, upper GI/pancreas, breast or colorectal cancers were included. The overall mean BSA was 1.79 m2 (95% CI 1.78–1.80) with a mean BSA for men of 1.91 m2 (1.90–1.92) and 1.71 m2 (1.70–1.72) for women. Results were consistent across the three centres. No significant differences were noted between treatment in the adjuvant or palliative setting in patients with breast or colorectal cancer. However, statistically significant, albeit small, differences were detected between some tumour groups. In view of the consistency of results between three geographically distinct UK cancer centres, we believe the results of this study may be generalised and used in future costings and budgeting for new chemotherapy agents in the UK.
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影响因子：
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作者：
Du Bois, D;Du Bois, EF
通讯作者：
Du Bois, EF
影响因子：
10.3
作者：
Baker, SD;Verweij, J;Sparreboom, A
通讯作者：
Sparreboom, A
影响因子：
168.9
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Colleoni, M;Li, SG;Goldhirsch, A
通讯作者：
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影响因子：
3
作者：
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通讯作者：
INGLE, JN
影响因子：
45.3
作者：
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通讯作者：
Schilsky, RL