The role of osteocytes in targeted bone remodeling: a mathematical model.
The role of osteocytes in targeted bone remodeling: a mathematical model.
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DOI：
10.1371/journal.pone.0063884
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Martin JA
中科院分区：
文献类型：
--
作者：
Graham JM;Ayati BP;Holstein SA;Martin JA
Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling. However, there is increasing evidence that osteocytes play important roles in the cycle of targeted bone remodeling, in serving as a significant source of RANKL to support osteoclastogenesis, and in secreting the bone formation inhibitor sclerostin. Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. We have aimed to give a simple, yet still tractable, model that remains faithful to the underlying system based on the known literature. This model extends and complements many of the existing mathematical models for bone remodeling, but can be used to explore aspects of the process of bone remodeling that were previously beyond the scope of prior modeling work. Through numerical simulations we demonstrate that our model can be used to explore theoretically many of the qualitative features of the role of osteocytes in bone biology as presented in recent literature.
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影响因子：
4.8
作者：
Gori, F;Hofbauer, LC;Riggs, BL
通讯作者：
Riggs, BL
DOI：
10.3233/thc-2009-0534
发表时间：
2009-01-01
期刊：
Technology and health care : official journal of the European Society for Engineering and Medicine
影响因子：
--
作者：
Heino, Terhi J;Kurata, Kosaku;Vaananen, H Kalervo
通讯作者：
Vaananen, H Kalervo
DOI：
10.1111/j.1749-6632.2011.06196.x
发表时间：
2011-01-01
期刊：
SKELETAL BIOLOGY AND MEDICINE I
影响因子：
--
作者：
Brunetti, Giacomina;Oranger, Angela;Colucci, Silvia
通讯作者：
Colucci, Silvia
影响因子：
15.9
作者：
Bell, NH
通讯作者：
Bell, NH
影响因子：
6.2
作者：
Cardoso, Luis;Herman, Brad C.;Schaffler, Mitchell B.
通讯作者：
Schaffler, Mitchell B.