Smoking Is Correlated With the Prognosis of Coronavirus Disease 2019 (COVID-19) Patients: An Observational Study.
Smoking Is Correlated With the Prognosis of Coronavirus Disease 2019 (COVID-19) Patients: An Observational Study.
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DOI：
10.3389/fphys.2021.634842
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发表时间：
2021
影响因子：
4
通讯作者：
Wu S
中科院分区：
文献类型：
--
作者：
Peng F;Lei S;Zhang Q;Zhong Y;Wu S
吸烟已被证明是许多疾病发展的危险因素。然而，关于吸烟与COVID-19的关系仍然存在争议。这项研究的目的是探讨吸烟在COVID-19中的作用。中国共有622名COVID-19患者入组研究。收集并分析相应的临床和实验室数据。同时，采用Kaplan-Meier曲线和考克斯回归分析，分析吸烟与COVID-19患者生存的关系。吸烟在COVID-19患者的非幸存者和幸存者之间具有统计学意义（P = 0.007）。男性吸烟率高于女性（91.9%比8.1%，P < 0.001）。与非吸烟者相比，吸烟的COVID-19患者脑血管疾病的发生率差异有统计学意义（9.7% vs. 3.4%，P = 0.017）。吸烟的COVID-19患者的白色血细胞计数（6.3 vs. 5.4; P = 0.037）、血红蛋白水平（139.0 vs. 127.0; P < 0.001）和肌酐水平（77.3 vs. 61.0; P < 0.001）显著升高。此外，吸烟患者的生存率低于非吸烟患者（对数秩P = 0.045）。在调整年龄、性别和基础疾病后，吸烟患者的死亡风险仍高于不吸烟患者（风险比[HR] 1.897，95%可信区间[CI]1.058-3.402，P = 0.032）。吸烟被认为是预测COVID-19预后的一个危险因素，吸烟患者的死亡风险可能高于不吸烟患者。
Cigarette smoking has been proven to be a risk factor in the development of many diseases. However, it remains controversial with respect to the relationship of smoking with COVID-19. The purpose of this study was to explore the role of smoking in COVID-19. A total of 622 patients with COVID-19 in China were enrolled in the study. Corresponding clinical and laboratory data were collected and analyzed. Meanwhile, Kaplan-Meier curve and Cox regression analysis were employed to analyze the association of smoking with survival in patients with COVID-19. Smoking was statistically significant comparing non-survivors and survivors of patients with COVID-19 (P = 0.007). Males had higher proportion of smoking than females (91.9% vs. 8.1%, P < 0.001). Compared with the non-smoker, there was significant statistical difference in the incidence of cerebrovascular disease in smoking patients with COVID-19 (9.7% vs. 3.4%, P = 0.017). White blood cell count (6.3 vs. 5.4; P = 0.037), hemoglobin level (139.0 vs. 127.0; P < 0.001), and creatinine level (77.3 vs. 61.0; P < 0.001) were significantly increased in COVID-19 patients who smoked. Moreover, smoking patients showed a worse survival compared with non-smoking patients (Log Rank P = 0.045). After adjustment for age, gender and underlying diseases, patients with smoking still had higher risk of mortality than that of non-smoking patients (hazard ratio[HR] 1.897, 95% confidence interval [CI]1.058–3.402, P = 0.032). Smoking was thought to be a risk factor in predicting the prognosis of COVID-19 and smoking patients might have a higher risk of mortality than that of the non-smoking patients.
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