Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters.

Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters.
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DOI:
10.2174/138920010791110917
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发表时间:
2010-01
影响因子:
2.3
通讯作者:
Guengerich FP
Guengerich FP
中科院分区:
医学4区
文献类型:
--
作者:
Rendic S;Guengerich FP

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本文是关于疾病和环境因素对人类细胞色素P450 (CYP)酶和转运体表达和/或活性影响的最新数据。这些数据以表格形式呈现(表1和表2),是先前发表的关于药物和其他化学品对CYP酶影响的摘要的延续。这里所展示的收集到的信息是由被引用的作者陈述的,如果引用了几篇参考文献,则包括最新发表的信息。强调了不同作者得出的不一致的结果和结论,然后讨论了主要发现。可搜索的数据库以Excel文件的形式提供,有关文件可用性的信息请联系相应的作者。
The present paper is an update of the data on the effects of diseases and environmental factors on the expression and/or activity of human cytochrome P450 (CYP) enzymes and transporters. The data are presented in tabular form (Tables 1 and 2) and are a continuation of previously published summaries on the effects of drugs and other chemicals on CYP enzymes. The collected information presented here is as stated by the cited author(s), and in cases when several references are cited the latest published information is included. Inconsistent results and conclusions obtained by different authors are highlighted, followed by discussion of the major findings. The searchable database is available as an Excel file, for information about file availability contact the corresponding author.
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