Hair cortisol as a biomarker of stress and resilience in South African mixed ancestry females
Hair cortisol as a biomarker of stress and resilience in South African mixed ancestry females
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头发皮质醇作为南非混血女性压力和恢复力的生物标志物
DOI：
10.1016/j.psyneuen.2019.104543
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发表时间：
2020
影响因子：
3.7
通讯作者：
Seedat
中科院分区：
文献类型：
--
作者：
van den Heuvel;du Plessis;Stalder;Suliman;Thorne;Kirschbaum;Seedat
背景头发皮质醇浓度（HCC）越来越多地被用作压力的生物标志物，然而关于HCC与保护因素（如弹性）之间的关系的研究有限。此外，测量HCC的研究需要考虑可能的混杂因素，这些因素尚未在足够多样化的settings.ObjectivesOur的目标是确定HCC的决定因素，在混合血统的成年人样本中，并调查HCC与自我感知的压力和弹性的相关性。（平均年龄46.5岁，SD= 15.0），自认为是混合血统，是2014年5月至2017年6月在南非开普敦进行的病例对照研究（共享根）的对照参与者。我们在未校正和校正的线性回归模型中研究了哪些社会人口统计学、毛发相关、临床和行为因素与HCC相关。此外，还研究了HCC与自我感知压力和弹性得分的关系。（Mdn4.4pg/ml;IQR2.8; 11.4）与头发产品的使用和母乳喂养显著正相关，与年龄、教育水平、阳光照射时间、储存时间显著负相关，并表现出与洗发频率显著相关的趋势，调整后的模型。HCC与CD-RISC评分呈负相关（adj β= − 0.179，p = 0.012），但与PSS评分无显著相关（adj β= − 0.001，p = 0.989）。结论我们在我们的样本中确定了HCC的特定决定因素，包括第一个表明自然条件下阳光照射对HCC有影响。这些潜在的混杂因素需要在未来研究的设计和分析中加以控制。肝细胞癌可能是一个生物标志物的弹性压力，而不是感知的压力。需要进一步研究在更多样化的环境和人群中测量HCC，并包括与弹性相关的结构。
BackgroundHair cortisol concentrations (HCC) are increasingly used as a biomarker of stress, however limited research exists regarding the relationship between HCC and protective factors, such as resilience. Additionally, studies measuring HCC need to account for possible confounders, and these factors have not been examined in sufficiently diverse settings.ObjectivesOur objectives were to identify determinants of HCC in a sample of mixed ancestry adults and investigate the association of HCC with measures of self-perceived stress and resilience.MethodsOur sample comprised 164 females (mean age 46.5 years,SD= 15.0), self-identifying as mixed ancestry, who were control participants in a case-control study (SHARED ROOTS), conducted in Cape Town, South Africa from May 2014 until June 2017. We examined which socio-demographic, hair related, clinical and behavioural factors were associated with HCC in both unadjusted and adjusted linear regression models. Furthermore, the relationship of HCC with self-perceived stress and resilience scores were also examined.ResultsHCC (Mdn4.4 pg/ml;IQR2.8; 11.4) were significantly positively associated with hair product use and breastfeeding, and significantly negatively associated with age, level of education, duration of sun exposure, duration of storage, and demonstrated a trend towards significance with frequency of hair washing, in adjusted models. HCC were inversely associated with CD-RISC scores (adj β= −0.179,p= 0.012) but were not significantly associated with PSS scores (adj β= −0.001,p= 0.989).ConclusionsWe identified specific determinants of HCC in our sample, including the first indication that sun exposure has an effect on HCC under naturalistic conditions. These potential confounders need to be controlled for in the design and analysis of future studies. HCC may be a biomarker of resilience to stress, rather than perceived stress. Further research measuring HCC in more diverse settings and populations and including constructs related to resilience are needed.
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影响因子：
3.7
作者：
Wester, Vincent L.;van der Wulp, Nils R. P.;van Rossum, Elisabeth F. C.
通讯作者：
van Rossum, Elisabeth F. C.
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
7.4
作者：
Connor, KM;Davidson, JRT
通讯作者：
Davidson, JRT
影响因子：
3.1
作者：
Ruiz-Robledillo, N.;De Andres-Garcia, S.;Moya-Albiol, L.
通讯作者：
Moya-Albiol, L.
头发中的皮质醇和代谢综合征。
DOI：
10.1210/jc.2013-1056
发表时间：
2013
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
T. Stalder;C. Kirschbaum;N. Alexander;S. Bornstein;Wei Gao;Robert Miller;Sabine Stark;J. Bosch;J. Fischer
通讯作者：
J. Fischer