Prevalence of hyperuricemia and the population attributable fraction of modifiable risk factors: Evidence from a general population cohort in China.
Prevalence of hyperuricemia and the population attributable fraction of modifiable risk factors: Evidence from a general population cohort in China.
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DOI：
10.3389/fpubh.2022.936717
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发表时间：
2022
影响因子：
5.2
通讯作者：
Zhang, Minying
中科院分区：
文献类型：
--
作者：
He, Huijing;Guo, Pei;He, Jiangshan;Zhang, Jingbo;Niu, Yujie;Chen, Shuo;Guo, Fenghua;Liu, Feng;Zhang, Rong;Li, Qiang;Ma, Shitao;Zhang, Binbin;Pan, Li;Shan, Guangliang;Zhang, Minying
关键词：
中国京津冀地区是世界级城市群之一，然而该地区高尿酸血症最新患病率的数据较为匮乏。超重/肥胖、饮酒、吸烟和久坐行为是血清尿酸（SUA）升高的可改变危险因素（MRFs），但它们对高尿酸血症的人群归因分值（PAFs）仍不明确。我们利用京津冀体检普通人群队列的基线数据，基于30158名年龄在18 - 80岁的参与者，计算了高尿酸血症的粗患病率和校正患病率。高尿酸血症定义为男性SUA > 420 μmol/L、女性SUA > 360 μmol/L，或目前正在使用降尿酸药物。超重/肥胖、饮酒、吸烟和久坐行为被视为可改变危险因素，并对其校正后的人群归因分值进行了估算。高尿酸血症的患病率为19.37%，其中男性为27.72%，女性为10.69%。男性超重、肥胖的人群归因分值及95%置信区间分别为16.25%（14.26 - 18.25%）和12.08%（11.40 - 12.77%），女性超重、肥胖的人群归因分值及95%置信区间分别为13.95%（12.31 - 15.59%）和6.35%（5.97 - 6.74%）。饮酒可解释男性4.64%（2.72 - 6.56%）的高尿酸血症病例，但在女性中无统计学意义。吸烟导致男性3.15%（1.09 - 5.21%）的病例，而女性中的比例要低得多（0.85%，0.49 - 1.22%）。与每天久坐时间 < 2小时相比，男性每天久坐2 - 4小时、4 - 6小时和超过6小时的人群归因分值分别为3.14%（1.34 - 4.93%）、6.72%（4.44 - 8.99%）和8.04%（4.95 - 11.13%）。未发现女性久坐时间与高尿酸血症有关。这些研究结果表明，高尿酸血症在这一具有代表性的中国成年普通人群中普遍存在，且存在显著的性别差异。四种可改变危险因素（超重/肥胖、饮酒、吸烟和久坐行为）在高尿酸血症病例中占相当比例。人群归因分值的估算有助于探究若去除这些可改变危险因素，高尿酸血症病例可能预防的预期比例，这凸显了生活方式干预对公共健康的重要意义。
Data on updated hyperuricemia prevalence in Beijing-Tianjin-Hebei (BTH) region in China, which is one of the world-class urban agglomerations, is sparse. Overweight/obesity, alcohol consumption, smoking and sedentary behavior are modifiable risk factors (MRFs) for elevated serum uric acid (SUA), but their population attributable fractions (PAFs) for hyperuricemia is still unclear. Using baseline data from the BTH Physical Examination General Population Cohort, we calculated the crude- and adjusted-prevalence of hyperuricemia based on the 30,158 participants aged 18–80 years. Hyperuricemia was defined as SUA >420 μmol/L in men and >360 μmol/L in women, or currently use of uric acid lowering drugs. Overweight/obesity, alcohol consumption, smoking and sedentary behavior were considered as MRFs and their adjusted PAFs were estimated. The prevalence of hyperuricemia was 19.37%, 27.72% in men and 10.69% in women. The PAFs and 95% confidence intervals for overweight, obesity were 16.25% (14.26–18.25%) and 12.08% (11.40–12.77%) in men, 13.95% (12.31–15.59%) and 6.35% (5.97–6.74%) in women, respectively. Alcohol consumption can explain 4.64% (2.72–6.56%) hyperuricemia cases in men, but with no statistical significance in women. Cigarette smoking contributed to 3.15% (1.09–5.21%) cases in men, but a much lower fraction in women (0.85%, 0.49–1.22%). Compared with sedentary time <2 h per day, the PAFs of 2–4 h, 4–6 h, and more than 6 h per day were 3.14% (1.34–4.93%), 6.72% (4.44–8.99%) and 8.04% (4.95–11.13%) in men, respectively. Sedentary time was not found to be associated with hyperuricemia in women. These findings concluded that hyperuricemia is prevalent in this representative Chinese adult general population with substantial sex difference. Four MRFs (overweight/obesity, alcohol consumption, cigarette smoking and sedentary behavior) accounted for a notable proportion of hyperuricemia cases. The PAF estimations enable the exploration of the expected proportion of hyperuricemia cases that could be prevented if the MRFs were removed, which warrants the public health significance of life-style intervention.
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影响因子：
4.9
作者：
Dong X;Li Y;Zhang L;Liu X;Tu R;Wang Y;Li R;Li L;Hou J;Mao Z;Huo W;Wang C
通讯作者：
Wang C
中国基础健康体检中高尿酸血症风险的随机森林预测模型
影响因子：
4
作者：
Gao Y;Jia S;Li D;Huang C;Meng Z;Wang Y;Yu M;Xu T;Liu M;Sun J;Jia Q;Zhang Q;Gao Y;Song K;Wang X;Fan Y
通讯作者：
Fan Y
影响因子：
8
作者：
Borghi, Claudio;Agabiti-Rosei, Enrico;Tsioufis, Konstantinos P.
通讯作者：
Tsioufis, Konstantinos P.
DOI：
10.1053/j.ajkd.2017.12.009
发表时间：
2018-06
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Johnson RJ;Bakris GL;Borghi C;Chonchol MB;Feldman D;Lanaspa MA;Merriman TR;Moe OW;Mount DB;Sanchez Lozada LG;Stahl E;Weiner DE;Chertow GM
通讯作者：
Chertow GM
中国百岁及近百岁老人高尿酸血症的危险因素
影响因子：
3.6
作者：
Han, Qiu-Xia;Zhang, Dong;Zhu, Han-Yu
通讯作者：
Zhu, Han-Yu