Independent and interactive effect of sitting time and physical activity on prevalence of hyperuricemia: the Henan Rural Cohort Study.
Independent and interactive effect of sitting time and physical activity on prevalence of hyperuricemia: the Henan Rural Cohort Study.
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DOI：
10.1186/s13075-020-02385-8
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发表时间：
2021-01-06
影响因子：
4.9
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Dong X;Li Y;Zhang L;Liu X;Tu R;Wang Y;Li R;Li L;Hou J;Mao Z;Huo W;Wang C
关于高尿酸血症(HUA)和中强度体力活动(PA)的研究很少，关于坐着时间(ST)的研究也很少。本研究的目的是探讨PA和ST与HUA的独立和交互作用。对河南省农村队列研究的38,855名年龄在18-79岁之间的研究对象进行了横断面分析。采用国际体力活动问卷(IPAQ)评定PA和ST水平。男性的血清尿酸水平为>； 7.0 mg/dL，女性为>； 6.0 mg/dL。采用多因素Logistic回归和线性回归模型分析PA、ST、HUA与血尿酸水平的独立相关性。用交互作用图显示PA和ST对HUA的交互作用。PA水平与血尿酸水平呈负相关(β− 为0.15，95%可信区间− 为0.22，− 为0.07)，ST与尿酸水平呈正相关(β为2.12，95%可信区间为1.90，2.34)。代谢当量(MET-小时/天)与HUA患病率降低相关(优势比(OR)为0.97，95%CI为0.96，0.99)，而每小时代谢当量增加与HUA增加相关(OR为1.05，95%CI为1.04，1.06)。PA和ST的交互作用显著(P<0.001， )。暴露于较高的ST与HUA患病率增加独立相关，而剧烈的PA与HUA患病率降低独立相关。同时，较高的日ST可减弱PA对HUA的保护作用。河南农村队列研究已在中国临床试验注册登记(注册号：CHICCTR-OOC-15006699)。
There are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) and also hardly regarding sitting time (ST). The purpose of this study was to examine the independent and interactive association of PA and ST with HUA. A cross-sectional analysis was performed on 38,855 participants (aged 18–79) enrolled from the Henan Rural Cohort Study at baseline (2015 to 2017). PA and ST levels were assessed by using the International Physical Activity Questionnaire (IPAQ). HUA was defined as a serum uric acid level of > 7.0 mg/dL for males and > 6.0 mg/dL for females. Multivariable logistic regression and linear regression models were applied to examine the independent association between PA or ST and HUA and serum uric acid level. Interaction plots were used to visualize the interaction effects of PA and ST on HUA. PA level was inversely related with serum uric acid level (β − 0.15, 95% confidence interval (CI) − 0.22, − 0.07), but ST was positively related with uric acid level (β 2.12, 95% CI 1.90, 2.34). Metabolic equivalent (MET-hour/day) was associated with decreased prevalence of HUA (odds ratio (OR) 0.97, 95% CI 0.96, 0.99), while per hour increased for ST was associated with increased HUA (OR 1.05, 95% CI 1.04, 1.06). The interaction of PA and ST was significant (P < 0.001). Exposure to higher ST was independently related to increased prevalence of HUA, while vigorous PA with a decreased HUA prevalence. Meanwhile, higher daily ST might attenuate the protective effect of PA on HUA. The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699).
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影响因子：
24
作者：
Chomistek, Andrea K.;Manson, JoAnn E.;Stefanick, Marcia L.;Lu, Bing;Sands-Lincoln, Megan;Going, Scott B.;Garcia, Lorena;Allison, Matthew A.;Sims, Stacy T.;LaMonte, Michael J.;Johnson, Karen C.;Eaton, Charles B.
通讯作者：
Eaton, Charles B.
影响因子：
5.7
作者：
Owen N;Healy GN;Matthews CE;Dunstan DW
通讯作者：
Dunstan DW
影响因子：
7.7
作者：
Hamilton, Marc T.;Hamilton, Deborah G.;Zderic, Theodore W.
通讯作者：
Zderic, Theodore W.
影响因子：
7.1
作者：
Matthews, Charles E.;George, Stephanie M.;Schatzkin, Arthur
通讯作者：
Schatzkin, Arthur
影响因子：
2.2
作者：
Dong, Xiaokang;Zhang, Honglei;Wang, Chongjian
通讯作者：
Wang, Chongjian