Mucin phenotypes and clinicopathological features of colorectal adenocarcinomas: Correlation with colorectal adenocarcinoma with enteroblastic differentiation.
Mucin phenotypes and clinicopathological features of colorectal adenocarcinomas: Correlation with colorectal adenocarcinoma with enteroblastic differentiation.
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结直肠腺癌的粘蛋白表型和临床病理学特征：与结直肠腺癌与肠母细胞分化的相关性。
DOI：
10.1016/j.prp.2022.153840
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发表时间：
2022
期刊：
影响因子：
2.8
通讯作者：
Yao T
中科院分区：
文献类型：
--
作者：
Kurosawa T;Murakami T;Yamashiro Y;Terukina H;Hayashi T;Saito T;Nojiri S;Sakamoto K;Nagahara A;Yao T
背景：结直肠癌（colorectal carcinoma，CRC）的粘蛋白表型与其生物学行为及预后有关.但是还没有研究在大量病例中评估表型特征。此外，大肠腺癌伴肠母细胞分化（CAED）是大肠癌的一种罕见亚型，预后差。本研究的目的是阐明结直肠癌中粘蛋白表型与肿瘤发生、生物学行为的相关性，并探讨CAED中粘蛋白表型的特点。方法和结果：采用免疫组化（IHC）方法将974例结直肠癌和42例CAED患者的结直肠癌粘蛋白表型分为大肠型、小肠型、胃型、混合型和未分型5种类型。在组织微阵列上用针对以下的抗体进行IHC：MUC2、MUC5AC、MUC6和⑶ 10。大肠型CRC预后较好，小肠型多见静脉侵犯和肝转移，胃型多见高组织学分级和淋巴管侵犯，混合型多起源于右半结肠，肿瘤体积较大，粘液型，但静脉侵犯和肝转移较少。而未分型患者的总生存期预后较差，有统计学意义。CAED多为小肠型或未分型。结论：CRCs的表型分型有助于判断其预后。小肠型和未分型肾癌预后差。我们推测CAED具有攻击性行为和预后不良可能反映了小肠型和未分类型的特点。
Background: The mucin phenotypes of colorectal carcinoma (CRC) is related to the biological behavior and prognosis. But there has been no studies evaluating phenotypic characteristics in a large number of cases. Furthermore, colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare subtype of CRC and having poor prognosis. The aims of this study were to clarify the correlation between mucin phenotypes and tumor development, including biological behavior in CRC, as well as to investigate characteristic of mucin phenotypes in CAED.Methods and results: 974 CRC cases and 42 CAED cases of CRCs were classified five types (large-intestinal, smallintestinal, gastric, mixed, and unclassified) of mucin phenotypes by using immunohistochemistry (IHC). IHC was performed on tissue microarrays with antibodies against followings: MUC2, MUC5AC, MUC6, and CD10. In CRCs, large-intestine type has a relatively better prognosis, small-intestinal type frequently shows venous invasions, and liver metastases, gastric type has more high-histological grades and lymphatic invasions, mixed type shows originating from the right side of the colon, larger tumor size and mucinous type, but less venous invasions and liver metastasis, whereas the unclassified type showed poorer prognosis in overall survival with statistical significance. The majority of CAED were found to be small-intestinal type or unclassified type. Conclusions: The phenotypic classification is useful for predicting the prognosis of CRCs. Small-intestinal type and unclassified type showed dismal prognosis in CRCs. We speculate that CAED having aggressive behavior and poor prognosis might reflect characteristics of small-intestinal and unclassified types.
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影响因子：
2.8
作者：
S. Fujita;H. Taniguchi;T. Yao;T. Shimoda;H. Ueno;T. Hirai;M. Ohue
通讯作者：
S. Fujita;H. Taniguchi;T. Yao;T. Shimoda;H. Ueno;T. Hirai;M. Ohue
影响因子：
3.5
作者：
Fujita, Kohei;Hirahashi, Minako;Tsuneyoshi, Masazumi
通讯作者：
Tsuneyoshi, Masazumi
结肠绒毛状肿瘤恶性转化的表型改变：特别参考与管状肿瘤的比较。
DOI：
--
发表时间：
2003
期刊：
Histopathology 43
影响因子：
--
作者：
Takata M;Yao T;Nishiyama K;Nawata H;Tsuneyoshi M.
通讯作者：
Tsuneyoshi M.
CD10和β-连环蛋白表达证明具有高恶性潜能的扁平腺瘤-癌序列：与息肉样腺瘤-癌序列不同的途径
影响因子：
6.4
作者：
Yuhki Koga;T. Yao;M. Hirahashi;Y. Kumashiro;Yuzuru Ohji;Tomomi Yamada;Mamoru Tanaka;M. Tsuneyoshi
通讯作者：
M. Tsuneyoshi
影响因子：
2.2
作者：
Koga, Yutaka;Hirahashi, Minako;Oda, Yoshinao
通讯作者：
Oda, Yoshinao