The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
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DOI：
10.1016/j.intimp.2020.107204
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发表时间：
2021-01
影响因子：
5.6
通讯作者：
Karampoor S
中科院分区：
文献类型：
--
作者：
Mirzaei R;Mahdavi F;Badrzadeh F;Hosseini-Fard SR;Heidary M;Jeda AS;Mohammadi T;Roshani M;Yousefimashouf R;Keyvani H;Darvishmotevalli M;Sani MZ;Karampoor S
继1918年甲型流感病毒（H1N1）大流行之后，2019年新型冠状病毒病（COVID-19）大流行给全球人口带来了重大的公共卫生问题。尽管已经做出了许多努力来揭示冠状病毒的潜在机制，但我们对COVID-19发病机制的认识仍然存在显着差距。先天免疫系统和适应性免疫系统在COVID-19大流行等病毒感染的命运中起着关键作用。MicroRNAs （miRNAs）是一种短的非编码RNA分子，是几乎所有细胞中不可或缺的调控分子。一些证据表明，mirna参与细胞生物学的基本机制，免疫系统的调节，以及许多类型疾病的发生和进展。病毒性呼吸道感染（VRIs）的免疫应答，包括流感病毒（IV）、呼吸道合胞病毒（RSV）和鼻病毒（RV），与mirna的异位表达相关。上皮细胞中miRNA表达的改变可能与慢性和急性气道感染的发病机制有关。因此，分析这些类型的核苷酸在抗病毒免疫反应中的作用以及miRNA靶基因的表征可能有助于了解宿主与病毒之间相互作用的机制，并在未来可能导致发现预防和治疗急性COVID-19感染的治疗策略。在这篇文章中，我们对mirna在不同vri中的功能的研究进行了综述，特别是在冠状病毒感染中，并提出了所有可用的治疗前景，以减轻病毒感染的负担。
The novel coronavirus disease 2019 (COVID-19) pandemic has imposed significant public health problems for the human populations worldwide after the 1918 influenza A virus (IVA) (H1N1) pandemic. Although numerous efforts have been made to unravel the mechanisms underlying the coronavirus, a notable gap remains in our perception of the COVID-19 pathogenesis. The innate and adaptive immune systems have a pivotal role in the fate of viral infections, such as COVID-19 pandemic. MicroRNAs (miRNAs) are known as short noncoding RNA molecules and appear as indispensable governors of almost any cellular means. Several lines of evidence demonstrate that miRNAs participate in essential mechanisms of cell biology, regulation of the immune system, and the onset and progression of numerous types of disorders. The immune responses to viral respiratory infections (VRIs), including influenza virus (IV), respiratory syncytial virus (RSV), and rhinovirus (RV), are correlated with the ectopic expression of miRNAs. Alterations of the miRNA expression in epithelial cells may contribute to the pathogenesis of chronic and acute airway infections. Hence, analyzing the role of these types of nucleotides in antiviral immune responses and the characterization of miRNA target genes might contribute to understanding the mechanisms of the interplay between the host and viruses, and in the future, potentially result in discovering therapeutic strategies for the prevention and treatment of acute COVID-19 infection. In this article, we present a general review of current studies concerning the function of miRNAs in different VRIs, particularly in coronavirus infection, and address all available therapeutic prospects to mitigate the burden of viral infections.
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影响因子：
3.3
作者：
Dickey LL;Hanley TM;Huffaker TB;Ramstead AG;O'Connell RM;Lane TE
通讯作者：
Lane TE
DOI：
10.1099/vir.0.044255-0
发表时间：
2012-11
期刊：
The Journal of general virology
影响因子：
--
作者：
Bakre A;Mitchell P;Coleman JK;Jones LP;Saavedra G;Teng M;Tompkins SM;Tripp RA
通讯作者：
Tripp RA
影响因子：
3.5
作者：
Chow JT;Salmena L
通讯作者：
Salmena L
影响因子：
9.3
作者：
Dickey LL;Worne CL;Glover JL;Lane TE;O'Connell RM
通讯作者：
O'Connell RM
影响因子：
3.7
作者：
Allantaz F;Cheng DT;Bergauer T;Ravindran P;Rossier MF;Ebeling M;Badi L;Reis B;Bitter H;D'Asaro M;Chiappe A;Sridhar S;Pacheco GD;Burczynski ME;Hochstrasser D;Vonderscher J;Matthes T
通讯作者：
Matthes T