MicroRNA 155 and viral-induced neuroinflammation.

MicroRNA 155 and viral-induced neuroinflammation.
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DOI:
10.1016/j.jneuroim.2017.01.016
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发表时间:
2017-07-15
影响因子:
3.3
通讯作者:
Lane TE
Lane TE
中科院分区:
医学4区
文献类型:
--
作者:
Dickey LL;Hanley TM;Huffaker TB;Ramstead AG;O'Connell RM;Lane TE

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MicroRNA (miRNA)调控基因表达正成为微生物感染后宿主免疫反应的一种日益被认可的机制。mirna是一种短的非编码rna,可抑制靶基因的翻译,并参与调节宿主免疫反应的许多活动,包括免疫细胞增殖、存活、扩增、分化、迁移、极化和效应功能的调节。这篇综述强调了哺乳动物编码的miR-155在病毒感染中枢神经系统后影响免疫反应的几个例子。
MicroRNA (miRNA) regulation of gene expression is becoming an increasingly recognized mechanism by which host immune responses are governed following microbial infection. miRNAs are short, non-coding RNAs that repress translation of target genes, and have been implicated in a number of activities that modulate host immune responses, including the regulation of immune cell proliferation, survival, expansion, differentiation, migration, polarization, and effector function. This review highlights several examples in which mammalian-encoded miR-155 influences immune responses following viral infection of the CNS.
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