Parathyroid hormone related peptide mRNA expression during murine postimplantation development: evidence for involvement in multiple differentiation processes.
Parathyroid hormone related peptide mRNA expression during murine postimplantation development: evidence for involvement in multiple differentiation processes.
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小鼠植入后发育过程中甲状旁腺激素相关肽 mRNA 表达：参与多种分化过程的证据。
DOI：
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发表时间：
1996
影响因子：
0.7
通讯作者：
L. Defize
中科院分区：
文献类型：
--
作者：
Marcel Karperien;P. Lanser;S. W. Laat;Johannes Boonstra;L. Defize
在这项研究中，我们描述了甲状旁腺激素相关肽(PTHrP)在小鼠移植后发育过程中的时空表达。从第5.5天起，滋养层细胞中可检测到PTHrP基因。此外，在第5.5天和第6.5天，抗子宫上隐窝的PC上皮细胞和与着床胚胎直接相邻的蜕膜内区的细胞表达PTHrP mRNA。这支持了先前的模型，在该模型中，顶层内胚层的形成受旁分泌机制的调节，该旁分泌机制涉及表达PTHrP的滋养层细胞和表达胚胎外内胚层细胞的受体。胚胎甲状旁腺素受体(PTHrP)在妊娠第10.5天在后脑顶端有第一次表达。从11.5天起，PTHrP mRNA在耳泡、半侧沟、后脑顶部及脉络丛、肺、心室上皮细胞、鼻窝内间充质细胞、鼻部真皮及所有软骨内成骨部位均可检测到。在胚胎发育过程中，PTHrP基因在胚胎外和胚胎组织中广泛表达，提示PTHrP参与了多种生长和分化过程。
In this study we describe the spatio-temporal expression of Parathyroid Hormone related Peptide (PTHrP) mRNA during murine postimplantation development from day 5.5 post coitum (pc) until day 12.5 pc. From day 5.5 pc and onwards PTHrP mRNA was detected in the trophoblast. In addition, at day 5.5 and 6.5 pc epithelial cells of the antimesometrial crypt and cells of the inner zone of the decidua directly adjacent to the implanted embryo expressed PTHrP mRNA. This supported a previous model in which parietal endoderm formation is regulated by a paracrine mechanism involving PTHrP expressing trophoblast cells and receptor expressing extra-embryonal endoderm cells. The first embryonal PTHrP mRNA expression was detected in the roof of the hindbrain at gestation day 10.5 pc. From day 11.5 pc and onwards PTHrP mRNA was detected in the otic vesicle, the semilateral channels, the roof of the hindbrain and later in the choroid plexus, in epithelial cells of the lung and heart ventricle, mesenchymal cells lining the nasal pit, the dermis of the snout and at all sites of endochondral bone formation. The widespread expression of PTHrP mRNA during embryogenesis in extra-embryonic and embryonic tissues suggests the involvement of the peptide in multiple growth and differentiation processes.
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胚胎癌细胞分化过程中甲状旁腺激素样蛋白及其受体的表达。
DOI：
10.1210/mend-4-4-638
发表时间：
1990
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Chan,SD;Strewler,GJ;King,KL;Nissenson,RA
通讯作者：
Nissenson,RA
影响因子：
4.6
作者：
O. Behrendtsen;C. Alexander;Z. Werb
通讯作者：
O. Behrendtsen;C. Alexander;Z. Werb
影响因子：
11.2
作者：
R. Campos;S. Asa;D. Drucker
通讯作者：
R. Campos;S. Asa;D. Drucker
甲状旁腺激素相关蛋白作为激素原：翻译后加工和受体相互作用。
影响因子：
20.3
作者：
Orloff,JJ;Reddy,D;dePapp,AE;Yang,KH;Soifer,NE;Stewart,AF
通讯作者：
Stewart,AF
DOI：
10.1073/pnas.91.3.1133
发表时间：
1994-02
影响因子：
11.1
作者：
J. Wysolmerski;A. Broadus;Jing Zhou;E. Fuchs;L. Milstone;W. Philbrick
通讯作者：
J. Wysolmerski;A. Broadus;Jing Zhou;E. Fuchs;L. Milstone;W. Philbrick