The impact of age on post-operative outcomes of colorectal cancer patients undergoing surgical treatment.
The impact of age on post-operative outcomes of colorectal cancer patients undergoing surgical treatment.
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DOI：
10.1186/1471-2407-5-153
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发表时间：
2005-12-02
期刊：
影响因子：
3.8
通讯作者：
Pavalkis D
中科院分区：
文献类型：
--
作者：
Latkauskas T;Rudinskaite G;Kurtinaitis J;Janciauskiene R;Tamelis A;Saladzinskas Z;Pavalkis D
该研究的目的是评估年龄对结直肠癌手术结果的影响。医院数据库中 1995 年至 2002 年期间接受结直肠癌治疗的患者分为两组：第 1 组 - 75 岁或以上的患者 (n = 154)，第 2 组 - 75 岁以下的患者 (n = 532)。在第一组中，对于结肠癌，近端肿瘤明显更常见（23% vs. 13.5%，p < 0.05），复杂病例更常见（46% vs. 33%，p = 0.002），就诊时肠梗阻更常见（40% vs. 26.5%，p = 0.001），并且需要更频繁的急诊手术（24% vs. 14%，p = 0.002）。 0.003）。老年组术后总体发病率较高，但手术并发症发生率无差异。总体 5 年生存率为 39% vs. 55% (p = 0.0006)，癌症相关 5 年生存率为 44% vs. 62% (p = 0.0006)。多变量Cox分析显示年龄不是术后死亡的独立危险因素。术前并发症和合并症、更晚期的疾病以及更高的术后非手术并发症发生率会对老年人结直肠癌手术后的术后结果产生不利影响。
the purpose of study was to evaluate the impact of age on outcomes in colorectal cancer surgery. patients on hospital database treated for colorectal cancer during the period 1995 – 2002 were divided into two groups: Group 1 – patients of 75 years or older (n = 154), and Group 2 – those younger than 75 years (n = 532). In Group 1, for colon cancers, proximal tumors were significantly more common (23% vs. 13.5%, p < 0.05), complicated cases were more frequent (46 % vs. 33%, p = 0.002), bowel obstruction more common at presentation (40% vs. 26.5%, p = 0.001), and more frequent emergency surgery required (24% vs. 14%, p = 0.003). Postoperative overall morbidity was higher in the elderly group, but with no differences in surgical complications rate. Overall 5 year survival was 39% vs. 55% (p = 0.0006) and cancer related 5 year survival was 44% vs. 62% (p = 0.0006). Multivariate Cox analysis showed that age was not an independent risk factor for postoperative mortality. Preoperative complications and co-morbidities, more advanced disease, and higher postoperative nonsurgical complication rates adversely affect postoperative outcomes after surgery for colorectal cancer in the elderly.
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