Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.
Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.
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DOI：
10.1002/mds.28532
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Donovan E
中科院分区：
文献类型：
--
作者：
Sarter M;Avila C;Kucinski A;Donovan E
在运动障碍如帕金森病（PD）中，胆碱能信号传导被基底前脑胆碱能神经元的损失以及纹状体胆碱能中间神经元（ChI）的异常活动破坏。多项证据表明，步态不平衡（PD的一个关键致残症状）可能是由高水平额叶皮质和皮质-纹状体处理的改变驱动的，这些改变通常与认知功能障碍相关。在这里，我们描述了皮质纹状体电路，介导的认知运动的相互作用，这种复杂的运动控制。导航动态的、障碍物丰富的环境的能力需要关于环境的信息与运动选择和排序的持续集成。外感受性和内感受性线索的皮层注意处理需要胆碱能活动的调制来指导纹状体运动控制。线索来源的信息主要通过额-纹状体神经元投射“转移”到纹状体回路。从帕金森氏症跌倒者和啮齿动物模型再现在这些患者中观察到的双重胆碱能-多巴胺能损失的证据支持从这种神经元回路引导的帕金森氏症福尔斯概念化中得出的主要假设。此外，在纹状体，ChIs构成一个特别关键的节点整合皮质与中脑多巴胺能传入，从而线索控制运动。增强或挽救皮质和纹状体机制的前胆碱能治疗可能改善帕金森病跌倒者的复杂运动控制，也可能改善患有步态障碍和福尔斯倾向的老年人的复杂运动控制。
In movement disorders such as Parkinson’s disease (PD), cholinergic signaling is disrupted by the loss of basal forebrain cholinergic neurons, as well as aberrant activity in striatal cholinergic interneurons (ChIs). Several lines of evidence suggest that gait imbalance, a key disabling symptom of PD, may be driven by alterations in high-level frontal cortical and cortico-striatal processing more typically associated with cognitive dysfunction. Here we describe the corticostriatal circuitry that mediates the cognitive–motor interactions underlying such complex movement control. The ability to navigate dynamic, obstacle-rich environments requires the continuous integration of information about the environment with movement selection and sequencing. The cortical-attentional processing of extero- and interoceptive cues requires modulation by cholinergic activity to guide striatal movement control. Cue-derived information is “transferred” to striatal circuitry primarily via fronto-striatal glutamatergic projections. Evidence from parkinsonian fallers and from a rodent model reproducing the dual cholinergic–dopaminergic losses observed in these patients supports the main hypotheses derived from this neuronal circuitry-guided conceptualization of parkinsonian falls. Furthermore, in the striatum, ChIs constitute a particularly critical node for the integration of cortical with midbrain dopaminergic afferents and thus for cues to control movements. Procholinergic treatments that enhance or rescue cortical and striatal mechanisms may improve complex movement control in parkinsonian fallers and perhaps also in older persons suffering from gait disorders and a propensity for falls.
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DOI：
10.1111/ejn.13715
发表时间：
2019-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Aceves Buendia JJ;Tiroshi L;Chiu WH;Goldberg JA
通讯作者：
Goldberg JA
影响因子：
3.2
作者：
Berry AS;Demeter E;Sabhapathy S;English BA;Blakely RD;Sarter M;Lustig C
通讯作者：
Lustig C
影响因子：
3.4
作者：
Brimblecombe KR;Threlfell S;Dautan D;Kosillo P;Mena-Segovia J;Cragg SJ
通讯作者：
Cragg SJ
影响因子：
11.2
作者：
Bohnen, Nicolaas, I;Kanel, Prabesh;Mueller, Martijn L. T. M.
通讯作者：
Mueller, Martijn L. T. M.
DOI：
10.1093/gerona/57.12.m785
发表时间：
2002-12-01
影响因子：
5.1
作者：
Brown, LA;Sleik, RJ;Gage, WH
通讯作者：
Gage, WH