Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
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DOI：
10.1016/j.cell.2018.07.020
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发表时间：
2018-08-23
期刊：
影响因子：
64.5
通讯作者：
Skiniotis G
中科院分区：
文献类型：
--
作者：
Qu Q;Takahashi YH;Yang Y;Hu H;Zhang Y;Brunzelle JS;Couture JF;Shilatifard A;Skiniotis G
The methylation of histone 3 Lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as COMplex of Proteins ASsociated with Set1 (COMPASS). The activity of the catalytic SET domain (Su(var)3–9, Enhancer-of-zeste and Trithorax) is endowed through forming a complex with a set of core proteins that are widely shared from yeast to humans. We obtained cryo-electron microscopy (cryo-EM) maps of the yeast Set1/COMPASS core complex at overall 4.0–4.4 Å resolution, providing insights into its structural organization and conformational dynamics. The Cps50 C-terminal tail weaves within the complex to provide a central scaffold for assembly. The SET domain, snugly positioned at the junction of the Y-shaped complex, is extensively contacted by Cps60 (Bre2), Cps50 (Swd1) and Cps30 (Swd3). The mobile SET-I motif of the SET domain is engaged by Cps30, explaining its key role in COMPASS catalytic activity towards higher H3K4 methylation states. The cryo-EM structure of the complete yeast COMPASS complex points to how it controls selective H3K4 mono-, di- and tri-methylation. Structure of a COMPASS histone H3K4 methyltransferase complex
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影响因子：
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作者：
Li, Yanjing;Han, Jianming;Zhang, Yuebin;Cao, Fang;Liu, Zhijun;Li, Shuai;Wu, Jian;Hu, Chunyi;Wang, Yan;Shuai, Jin;Chen, Juan;Cao, Liaoran;Li, Dangsheng;Shi, Pan;Tian, Changlin;Zhang, Jian;Dou, Yali;Li, Guohui;Chen, Yong;Lei, Ming
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Lei, Ming
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Avdic, Vanja;Zhang, Pamela;Couture, Jean-Francois
通讯作者：
Couture, Jean-Francois
DOI：
10.1107/s0907444909052925
发表时间：
2010-02
期刊：
Acta crystallographica. Section D, Biological crystallography
影响因子：
--
作者：
Adams PD;Afonine PV;Bunkóczi G;Chen VB;Davis IW;Echols N;Headd JJ;Hung LW;Kapral GJ;Grosse-Kunstleve RW;McCoy AJ;Moriarty NW;Oeffner R;Read RJ;Richardson DC;Richardson JS;Terwilliger TC;Zwart PH
通讯作者：
Zwart PH
影响因子：
4.8
作者：
Krogan, NJ;Dover, J;Shilatifard, A
通讯作者：
Shilatifard, A