Optical coherence tomography angiography of optic disc perfusion in glaucoma.
Optical coherence tomography angiography of optic disc perfusion in glaucoma.
复制标题
DOI：
10.1016/j.ophtha.2014.01.021
复制
发表时间：
2014-07
期刊：
影响因子：
13.7
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
目的：应用光学相干断层扫描（OCT）血管造影技术比较正常人和青光眼患者视盘血流灌注情况，探讨青光眼患者视盘血流灌注的变化。观察性横断面研究。24名正常人和11名青光眼患者被包括在内。每名受试者的一只眼睛由高速1050 nm波长扫频光源OCT仪器扫描。采用分裂谱振幅去相关血管造影算法（SSADA）计算三维视盘血管造影。根据4次配准扫描计算椎间盘血流指数。共聚焦扫描激光检眼镜（cSLO）用于测量椎间盘边缘面积，立体摄影用于评估杯/盘比。在椎间盘上的宽视野OCT扫描用于测量视网膜神经纤维层（NFL）厚度。通过变异系数（CV）评估变异性。通过敏感性和特异性评估诊断准确性。青光眼和正常组之间的比较通过Wilcoxon秩和检验进行分析。通过线性回归评估椎间盘血流指数、结构评估和视野（VF）参数之间的相关性。在正常椎间盘中，OCT血管造影可见致密的微血管网。在青光眼患者中，该网络明显减弱。视盘血流指数的访视内重复性、访视间重复性和正常人群变异性分别为1.2%、4.2%和5.0%CV。青光眼组的椎间盘血流指数降低了25%（p = 0.003）。使用优化的临界值，灵敏度和特异性均为100%。血流指数与VF模式标准差高度相关（R2 = 0.752，p = 0.001）。即使考虑了年龄、杯/盘面积比、NFL和边缘面积，这些相关性也是显著的。OCT血管造影，由新的SSADA算法生成，可重复测量视盘灌注。OCT血管造影可用于评价青光眼和青光眼进展。
To compare optic disc perfusion between normal and glaucoma subjects using optical coherence tomography (OCT) angiography and detect optic disc perfusion changes in glaucoma. Observational, cross-sectional study. Twenty-four normal subjects and 11 glaucoma patients were included. One eye of each subject was scanned by a high-speed 1050 nm wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography algorithm (SSADA) was used to compute three-dimensional optic disc angiography. A disc flow index was computed from four registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used to evaluate cup/disc ratios. Wide field OCT scans over the discs were used to measure retinal nerve fiber layer (NFL) thickness. Variability was assessed by coefficient of variation (CV). Diagnostic accuracy was assessed by sensitivity and specificity. Comparisons between glaucoma and normal groups were analyzed by Wilcoxon rank-sum test. Correlations between disc flow index, structural assessments, and visual field (VF) parameters were assessed by linear regression. In normal discs, a dense microvascular network was visible on OCT angiography. This network was visibly attenuated in glaucoma subjects. The intra-visit repeatability, inter-visit reproducibility, and normal population variability of the optic disc flow index were 1.2%, 4.2%, and 5.0% CV respectively. The disc flow index was reduced by 25% in the glaucoma group (p = 0.003). Sensitivity and specificity were both 100% using an optimized cutoff. The flow index was highly correlated with VF pattern standard deviation (R2 = 0.752, p = 0.001). These correlations were significant even after accounting for age, cup/disc area ratio, NFL, and rim area. OCT angiography, generated by the new SSADA algorithm, repeatably measures optic disc perfusion. OCT angiography could be useful in the evaluation of glaucoma and glaucoma progression.
登录
查看更多内容
影响因子：
3.4
作者：
Kraus MF;Potsaid B;Mayer MA;Bock R;Baumann B;Liu JJ;Hornegger J;Fujimoto JG
通讯作者：
Fujimoto JG
DOI：
10.2147/opth.s22093
发表时间：
2011
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Aizawa N;Yokoyama Y;Chiba N;Omodaka K;Yasuda M;Otomo T;Nakamura M;Fuse N;Nakazawa T
通讯作者：
Nakazawa T
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
--
作者：
De Moraes, Carlos Gustavo V.;Juthani, Viral J.;Ritch, Robert
通讯作者：
Ritch, Robert
影响因子：
13.7
作者：
Leske, M. Cristina;Heijl, Anders;Yang, Zhongming
通讯作者：
Yang, Zhongming