It's What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets.
It's What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets.
复制标题
DOI：
10.3389/fendo.2022.842603
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Matveyenko AV
中科院分区：
文献类型：
--
作者：
Brown MR;Matveyenko AV
我们不断变化的现代环境是许多慢性疾病，特别是2型糖尿病（T2 DM）患病率增加的重要原因。虽然现代已经迎来了许多变化，我们的日常生活条件，改变“什么”和“什么时候”，我们吃的似乎不成比例地燃料T2 DM的上升。胰岛是生物体葡萄糖稳态的关键生物控制器，因此在协调对环境因素的反应以通过内分泌输出的微妙平衡来保持健康方面发挥着巨大的作用。成功和失败的适应动态环境刺激已被假定发生由于与胰岛分泌功能和生存相关的途径的转录和表观遗传调控的变化。因此，在这篇综述中，我们研究和评估了目前的证据阐明关键的表观遗传机制和转录程序的胰岛的协调反应之间的相互作用的时间和组成的饮食营养素共同现代生活方式。随着下一代测序技术的迅猛发展，沿着新的信息学和组学方法的发展，未来的工作将继续揭示胰岛生物学中的环境-表观遗传关系，目标是鉴定与T2 DM中胰岛扰动相关的转录和表观遗传靶点。
Our ever-changing modern environment is a significant contributor to the increased prevalence of many chronic diseases, and particularly, type 2 diabetes mellitus (T2DM). Although the modern era has ushered in numerous changes to our daily living conditions, changes in “what” and “when” we eat appear to disproportionately fuel the rise of T2DM. The pancreatic islet is a key biological controller of an organism’s glucose homeostasis and thus plays an outsized role to coordinate the response to environmental factors to preserve euglycemia through a delicate balance of endocrine outputs. Both successful and failed adaptation to dynamic environmental stimuli has been postulated to occur due to changes in the transcriptional and epigenetic regulation of pathways associated with islet secretory function and survival. Therefore, in this review we examined and evaluated the current evidence elucidating the key epigenetic mechanisms and transcriptional programs underlying the islet’s coordinated response to the interaction between the timing and the composition of dietary nutrients common to modern lifestyles. With the explosion of next generation sequencing, along with the development of novel informatic and –omic approaches, future work will continue to unravel the environmental-epigenetic relationship in islet biology with the goal of identifying transcriptional and epigenetic targets associated with islet perturbations in T2DM.
登录
查看更多内容
影响因子：
29
作者：
Akerman I;Tu Z;Beucher A;Rolando DMY;Sauty-Colace C;Benazra M;Nakic N;Yang J;Wang H;Pasquali L;Moran I;Garcia-Hurtado J;Castro N;Gonzalez-Franco R;Stewart AF;Bonner C;Piemonti L;Berney T;Groop L;Kerr-Conte J;Pattou F;Argmann C;Schadt E;Ravassard P;Ferrer J
通讯作者：
Ferrer J
影响因子：
9.8
作者：
Bordone L;Motta MC;Picard F;Robinson A;Jhala US;Apfeld J;McDonagh T;Lemieux M;McBurney M;Szilvasi A;Easlon EJ;Lin SJ;Guarente L
通讯作者：
Guarente L
影响因子：
15.9
作者：
Brown, Matthew R.;Holmes, Heather;Matveyenko, Aleksey, V
通讯作者：
Matveyenko, Aleksey, V
影响因子：
4.2
作者：
Chicco, A;D'Alessandro, ME;Lombardo, YB
通讯作者：
Lombardo, YB
影响因子：
--
作者：
Al-Khalifa, A.;Mathew, T. C.;Dashti, H.
通讯作者：
Dashti, H.