An Emerging Group of Membrane Property Sensors Controls the Physical State of Organellar Membranes to Maintain Their Identity
An Emerging Group of Membrane Property Sensors Controls the Physical State of Organellar Membranes to Maintain Their Identity
复制标题
一组新兴的膜特性传感器控制细胞器膜的物理状态以保持其身份
作者：
Radanović;Reinhard;Ballweg
真核细胞的生物膜具有敏感的监视系统，以建立、感知和维持最终定义细胞器身份的特征性物理化学性质。它们对膜稳态至关重要，并在细胞信号传导、蛋白质分选和囊泡载体的形成中发挥积极作用。在这里，我们比较了分子机制的Mga2和Ire 1，两个传感器参与调节脂肪酸去饱和和响应未折叠的蛋白质和脂质双层应力，以确定其共性和专业化。我们将推测在其他细胞器的膜特性传感器的细胞意义，并讨论其假定的机制。基于这些发现，我们提出膜特性传感器作为一类新兴的蛋白质，具有广泛的影响，细胞器的通信和功能。
The biological membranes of eukaryotic cells harbor sensitive surveillance systems to establish, sense, and maintain characteristic physicochemical properties that ultimately define organelle identity. They are fundamentally important for membrane homeostasis and play active roles in cellular signaling, protein sorting, and the formation of vesicular carriers. Here, we compare the molecular mechanisms of Mga2 and Ire1, two sensors involved in the regulation of fatty acid desaturation and the response to unfolded proteins and lipid bilayer stress in order to identify their commonalities and specializations. We will speculate on the cellular significance of membrane property sensors in other organelles and discuss their putative mechanisms. Based on these findings, we propose membrane property sensors as an emerging class of proteins with wide implications for organelle communication and function.
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影响因子：
4
作者：
Cohen N;Breker M;Bakunts A;Pesek K;Chas A;Argemí J;Orsi A;Gal L;Chuartzman S;Wigelman Y;Jonas F;Walter P;Ernst R;Aragón T;van Anken E;Schuldiner M
通讯作者：
Schuldiner M
影响因子：
5.5
作者：
Bernardino de la Serna J;Schütz GJ;Eggeling C;Cebecauer M
通讯作者：
Cebecauer M
影响因子：
7.8
作者：
Kimata, Yukio;Ishiwata-Kimata, Yuki;Ito, Tatsuhiko;Hirata, Aiko;Suzuki, Tomohide;Oikawa, Daisuke;Takeuchi, Masato;Kohno, Kenji
通讯作者：
Kohno, Kenji
影响因子：
4.8
作者：
Garcia-Saez, Ana J.;Chiantia, Salvatore;Schwille, Petra
通讯作者：
Schwille, Petra
影响因子：
16
作者：
Surma, Michal A.;Klose, Christian;Peng, Debby;Shales, Michael;Mrejen, Caroline;Stefanko, Adam;Braberg, Hannes;Gordon, David E.;Vorkel, Daniela;Ejsing, Christer S.;Farese, Robert, Jr.;Simons, Kai;Krogan, Nevan J.;Ernst, Robert
通讯作者：
Ernst, Robert