The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder.

The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder.
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DOI:
10.3389/fnbeh.2021.683780
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发表时间:
2021
影响因子:
3
通讯作者:
Muzaimi M
Muzaimi M
中科院分区:
医学3区
文献类型:
--
作者:
Iman IN;Yusof NAM;Talib UN;Ahmad NAZ;Norazit A;Kumar J;Mehat MZ;Jayabalan N;Muthuraju S;Stefaniuk M;Kaczmarek L;Muzaimi M

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物质使用障碍(SUD)的动物模型的使用在物质滥用和成瘾的行为和分子机制的调查作出了重要贡献。在这里,我们回顾了一个新颖而全面的行为平台,使用全自动学习系统IntelliCage来描述啮齿动物的成瘾特征。该系统同时捕捉基本的行为导航,奖励偏好和厌恶,以及多维度的复杂行为和认知功能的群体圈养啮齿动物。它可以可靠地捕获和跟踪与物质成瘾发展相关的运动和认知模式改变。因此,IntelliCage学习系统为啮齿动物SUD模型的高通量筛选提供了潜在的高效,灵活和灵敏的工具。
The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
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