Chronic risperidone administration leads to greater amphetamine-induced conditioned place preference.
Chronic risperidone administration leads to greater amphetamine-induced conditioned place preference.
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慢性利培酮给药导致更大的安非他明诱导的条件性位置偏爱。
DOI：
10.1016/j.neuropharm.2020.108276
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发表时间：
2020-11-15
影响因子：
4.7
通讯作者：
Pauly JR
中科院分区：
文献类型：
--
作者：
Bardgett ME;Downnen T;Crane C;Baltes Thompson EC;Muncie B;Steffen SA;Yates JR;Pauly JR
利培酮是一种非典型的抗精神病药物，越来越多地在儿童中用于治疗ADHD和品行障碍的症状。在大鼠中，发育期间服用利培酮伴随着成年期运动活动的增加，以及对苯丙胺的运动刺激效应的高度敏感性。这项研究比较了长期服用利培酮(3.0 mg/kg，S.C.)组大鼠对苯丙胺奖赏效应的敏感性，以条件性位置偏爱(CPP)衡量。在发育期间(出生后14-42天)或成年期(出生后77-105天)。在最后一次注射利培酮后的第三周和第四周，分别测量了新型测试笼子中的运动活动和苯丙胺诱导的CPP。在生命早期服用利培酮的雌性大鼠比其他任何一组受试者都更活跃。以前服用利培酮会增加苯丙胺CPP，而不分性别，这种影响在发育治疗组表现得更加突出。安非他明的主要靶点前脑多巴胺转运体的密度也在生命早期服用利培酮的大鼠中进行了量化，发现在内侧前、后和腹尾状核中的密度降低。这些结果表明，慢性利培酮治疗改变了后来的运动活动和对苯丙胺增强效应的敏感性，可能是通过与降低前脑多巴胺转运体密度有关的机制。
Risperidone is an atypical antipsychotic drug used increasingly in children to manage symptoms of ADHD and conduct disorder. In rats, developmental risperidone administration is accompanied by increased locomotor activity during adulthood, as well as heightened sensitivity to the locomotor stimulating effects of amphetamine. This study compared sensitivity to the rewarding effects of amphetamine, as measured by conditioned place preference (CPP), between groups of rats administered chronic risperidone (3.0 mg/kg, s.c.) during development (postnatal days 14-42) or adulthood (postnatal days 77-105). Locomotor activity in a novel test cage and amphetamine-induced CPP were measured beginning three and four weeks, respectively, after the final risperidone injection. Female rats administered risperidone early in life were more active than any other group tested. Previous risperidone administration enhanced amphetamine CPP regardless of sex, and this effect appeared more prominent in the developmentally treated group. The density of forebrain dopamine transporters, a primary target of amphetamine, was also quantified in rats administered risperidone early in life and found to be reduced in the medial anterior, posterior, and ventral caudate nucleus. These results suggest that chronic risperidone treatment modifies later locomotor activity and sensitivity to the reinforcing effects of amphetamine, perhaps via a mechanism related to decreased forebrain dopamine transporter density.
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影响因子：
5.6
作者：
Choi, Yong Kee;Moran-Gates, Taylor;Gardner, Matthew P.;Tarazi, Frank I.
通讯作者：
Tarazi, Frank I.
DOI：
10.1016/j.pbb.2015.02.019
发表时间：
2015-05
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Lenoir M;Starosciak AK;Ledon J;Booth C;Zakharova E;Wade D;Vignoli B;Izenwasser S
通讯作者：
Izenwasser S
影响因子：
2.7
作者：
Bardgett，Mark E.;Crane，Casey;Downnen，Tyler
通讯作者：
Downnen，Tyler
影响因子：
2.3
作者：
Bardgett, Mark E.;Franks-Henry, Julie M.;Griffith, Molly S.
通讯作者：
Griffith, Molly S.
影响因子：
6.6
作者：
Bedard, Anne-Marie;Maheux, Jerome;Samaha, Anne-Noel
通讯作者：
Samaha, Anne-Noel