The secreted kinase ROP18 defends Toxoplasma's border.
The secreted kinase ROP18 defends Toxoplasma's border.
复制标题
DOI：
10.1002/bies.201100054
复制
发表时间：
2011-09
期刊：
影响因子：
4
通讯作者：
Sibley, L. David
中科院分区：
文献类型：
--
作者：
Fentress, Sarah J.;Sibley, L. David
刚地弓形虫是一种非常成功的寄生虫，能够通过主动侵入有核宿主细胞并形成一个修饰的区室来感染几乎所有的温血动物，在细胞质中进行复制。含有寄生虫的空泡甚至在专业吞噬细胞如巨噬细胞中提供了安全的避难所，这些吞噬细胞通常会破坏外来微生物。为了消除寄生虫，宿主上调免疫相关的p47 GTP酶（IRG）家族，其被募集到含有寄生虫的空泡，导致膜破裂和寄生虫的消化。为了避免这种命运，高毒力的弓形虫株用一种分泌型丝氨酸/苏氨酸激酶（称为ROP 18）包被其空泡的外表面。在这个宿主-病原体界面，ROP 18磷酸化并使IRG失活，从而保护寄生虫免于杀死。这些发现揭示了寄生虫解除宿主先天免疫的新分子机制
Toxoplasma gondii is a highly successful parasite capable of infecting virtually all warm-blooded animals by actively invading nucleated host cells and forming a modified compartment where it replicates within the cytosol. The parasite-containing vacuole provides a safe haven even in professional phagocytes such as macrophages, which normally destroy foreign microbes. In effort to eliminate the parasite, the host up-regulates a family of immunity-related p47 GTPases (IRGs), which are recruited to the parasite-containing vacuole, resulting in membrane rupture and digestion of the parasite. To avoid this fate, highly virulent strains of Toxoplasma coat the external surface of their vacuole with a secretory serine/threonine kinase, known as ROP18. At this host-pathogen interface, ROP18 phosphorylates and inactivates IRGs, thereby protecting the parasite from killing. These findings reveal a novel molecular mechanism by which the parasite disarms host innate immunity
登录
查看更多内容
影响因子：
3.4
作者：
Khaminets A;Hunn JP;Könen-Waisman S;Zhao YO;Preukschat D;Coers J;Boyle JP;Ong YC;Boothroyd JC;Reichmann G;Howard JC
通讯作者：
Howard JC
影响因子：
5.4
作者：
Broberg, Christopher A.;Orth, Kim
通讯作者：
Orth, Kim
影响因子：
3.1
作者：
Howe, DK;Summers, BC;Sibley, LD
通讯作者：
Sibley, LD
影响因子：
4.8
作者：
Bradley, PJ;Ward, C;Boothroyd, JC
通讯作者：
Boothroyd, JC
影响因子：
56.9
作者：
Kim, Bae-Hoon;Shenoy, Avinash R.;MacMicking, John D.
通讯作者：
MacMicking, John D.