Tipping the balance by manipulating post-translational modifications.

Tipping the balance by manipulating post-translational modifications.
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DOI:
10.1016/j.mib.2009.12.004
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发表时间:
2010-02
影响因子:
5.4
通讯作者:
Orth, Kim
Orth, Kim
中科院分区:
生物学2区
文献类型:
--
作者:
Broberg, Christopher A.;Orth, Kim

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细菌在感染期间使用各种机制来确保它们的生存,包括通过III型分泌系统将毒力因子输送到受感染的细胞中。这些因子表现出不同的活性,在许多情况下模仿宿主用来防御感染的真核机制。在这里,我们描述了一类使用翻译后修饰的效应器,一些是可逆的,另一些是不可逆的,以操纵宿主信号系统来颠覆宿主的反应。
Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use posttranslational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
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