Cellular sources of extracellular matrix in hepatic fibrosis.
Cellular sources of extracellular matrix in hepatic fibrosis.
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肝纤维化中细胞外基质的细胞来源。
DOI：
10.1016/j.cld.2008.07.008
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发表时间：
2008-11
影响因子：
5.1
通讯作者：
Wells RG
中科院分区：
文献类型：
--
作者：
Wells RG
肝纤维化的标志是细胞外基质的沉积增加和异常。众所周知，肝星状细胞是纤维状胶原和肝瘢痕的其他组分的主要来源，但现在认识到，它们只是患病肝脏中许多潜在的纤维化细胞群之一。门静脉成纤维细胞以及来自骨髓的循环间充质细胞也是纤维化中基质蛋白的重要来源。最近的数据表明，肝细胞和胆管上皮细胞经历上皮间质转化，类似地假设纤维化表型。窦状隙内皮细胞和肝细胞都产生在肝脏健康和疾病中重要的特异性基质蛋白。未来的挑战将是以疾病特异性的方式更明确地定义这些不同的纤维化细胞群在纤维化中的作用。
The deposition of increased and abnormal extracellular matrix is the hallmark of liver fibrosis. Hepatic stellate cells are well known as the major source of the fibrillar collagens and other components of the liver scar, but it is now appreciated that they are only one of many potentially fibrogenic cell populations in the diseased liver. Portal fibroblasts as well as circulating mesenchymal cells derived from the bone marrow are also important sources of matrix proteins in fibrosis. Recent data suggest that hepatocytes and biliary epithelial cells undergo an epithelial to mesenchymal transition, similarly assuming a fibrogenic phenotype. Sinusoidal endothelial cells and hepatocytes both produce specific matrix proteins important in liver health and disease. The challenge of the future will be to define more explicitly the roles of these different fibrogenic cell populations in fibrosis in a disease-specific way.
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DOI：
10.1016/j.biocel.2005.08.021
发表时间：
2006-02-01
影响因子：
4
作者：
Guyot, C;Lepreux, S;Desmoulière, A
通讯作者：
Desmoulière, A
影响因子：
3.7
作者：
del Castillo, Gaelle;Murillo, Miguel M.;Fabregat, Isabel
通讯作者：
Fabregat, Isabel
影响因子：
6.4
作者：
BARDADIN, KA;DESMET, VJ
通讯作者：
DESMET, VJ
DOI：
10.1073/pnas.82.24.8681
发表时间：
1985-12-01
影响因子：
11.1
作者：
FRIEDMAN, SL;ROLL, FJ;BISSELL, DM
通讯作者：
BISSELL, DM
影响因子：
2.3
作者：
Herbst, H;Frey, A;Schuppan, D
通讯作者：
Schuppan, D