Enhanced fluorescence imaging performance of hydrophobic colloidal ZnO nanoparticles by a facile method

Enhanced fluorescence imaging performance of hydrophobic colloidal ZnO nanoparticles by a facile method
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通过简便的方法增强疏水性胶体ZnO纳米颗粒的荧光成像性能

DOI:
10.1016/j.jallcom.2014.09.072
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发表时间:
2015-01
影响因子:
6.2
通讯作者:
Xiaosheng Tang
Xiaosheng Tang
中科院分区:
材料科学2区
文献类型:
--
作者:
Zhigang Zang;Xiaosheng Tang

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本文介绍了一种利用双相反应制备氧化锌纳米粒子的简便方法。合成的ZnO纳米颗粒形貌呈花状。在有机锌前驱体存在的情况下,过氧化氢作为一种独特的供氧源促进ZnO的形成。合成的ZnO纳米颗粒在水环境中也表现出稳定性和溶解度。采用透射电子显微镜(TEM)、x射线衍射仪(XRD)、紫外可见光谱和光致发光光谱对ZnO纳米粒子的结构和性能进行了研究。制备的疏水胶体ZnO纳米粒子可以被修饰成与氨基乙醇·HCl交换的水溶性配体,同时保持其光致发光性能。此外,还论证了水溶性氧化锌纳米粒子在生物标记方面的潜在应用。这些研究结果不仅为ZnO胶体纳米颗粒在生物荧光成像中的有效应用提供了理论依据,而且促进了其在靶向药物递送领域的应用。
A facile synthesis method for the formation of ZnO nanoparticles by using a double-phase reaction was demonstrated in this paper. The morphology of the synthesized ZnO nanoparticles shows a flower-shape. Hydrogen peroxide was used as a unique oxygenic source to promote the formation of ZnO in the presence of organic zinc precursor. The as-synthesized ZnO nanoparticles also show a stability and solubility in the aqueous environment. The structure and properties of ZnO nanoparticles were investigated by the transmission electron microscopy (TEM) and X-ray diffraction (XRD) as well as UV–vis and photoluminescence spectroscopy. The as-prepared hydrophobic colloidal ZnO nanoparticles could be modified to become water-solublevialigand exchange with amineothanethiol⋅HCl while retaining the photoluminescence properties. In addition, the potential application for biological label of water-soluble ZnO nanoparticles were also demonstrated. These results not only have applications towards using colloidal ZnO nanoparticles effectively in biological fluorescence imaging, but also promote its application in the field of targeted drug delivery.
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