Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.

Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.
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DOI:
10.1021/nn3037094
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发表时间:
2013-03-26
期刊:
影响因子:
17.1
通讯作者:
Oreffo, Richard O. C.
Oreffo, Richard O. C.
中科院分区:
材料科学1区
文献类型:
--
作者:
Kingham, Emmajayne;Oreffo, Richard O. C.

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胚胎干细胞(ESC)和诱导多能干细胞(iPSC)具有分化为人体任何特化细胞类型的能力,因此,ESC/iPSC衍生的细胞类型为再生医学提供了巨大的潜力。然而,实现这一潜力的关键需要对干细胞生物学、维持干细胞的技术以及操纵细胞以有效地引导细胞分化为所需细胞类型的策略有很强的理解。随着纳米科学和工程不断产生新的纳米技术平台,它通知,渗透和冲击日常生活的许多方面,这是毫不奇怪的干细胞研究正在转向纳米技术的发展,以回答研究问题,并克服再生医学的障碍。在这里,我们讨论了使用纳米材料操纵ESC和iPSC的最新进展,并强调了这一研究领域未来的挑战。
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine. However, key to realizing this potential requires a strong understanding of stem cell biology, techniques to maintain stem cells, and strategies to manipulate cells to efficiently direct cell differentiation toward a desired cell type. As nanoscale science and engineering continues to produce novel nanotechnology platforms, which inform, infiltrate, and impinge on many aspects of everyday life, it is no surprise that stem cell research is turning toward developments in nanotechnology to answer research questions and to overcome obstacles in regenerative medicine. Here we discuss recent advances in ESC and iPSC manipulation using nanomaterials and highlight future challenges within this area of research.
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