Visualizing metal ions in cells: an overview of analytical techniques, approaches, and probes.
Visualizing metal ions in cells: an overview of analytical techniques, approaches, and probes.
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DOI:
10.1016/j.bbamcr.2012.04.001
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发表时间:
2012-09
期刊:
影响因子:
--
通讯作者:
Palmer AE
中科院分区:
文献类型:
--
作者:
Dean KM;Qin Y;Palmer AE
Quantifying the amount and defining the location of metal ions in cells and organisms are critical steps in understanding metal homeostasis and how dyshomeostasis causes or is a consequence of disease. A number of recent advances have been made in the development and application of analytical methods to visualize metal ions in biological specimens. Here, we briefly summarize these advances before focusing in more depth on probes for examining transition metals in living cells with high spatial and temporal resolution using fluorescence microscopy.
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