The modified Glasgow prognostic score as a predictor of survival after hepatectomy for colorectal liver metastases.
The modified Glasgow prognostic score as a predictor of survival after hepatectomy for colorectal liver metastases.
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DOI：
10.1245/s10434-013-3342-6
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发表时间：
2014-05
影响因子：
3.7
通讯作者：
Endo I
中科院分区：
文献类型：
--
作者：
Nakagawa K;Tanaka K;Nojiri K;Kumamoto T;Takeda K;Ueda M;Endo I
以炎症为基础的格拉斯哥预后评分(GPS)已被证明是多种肿瘤的预后指标。探讨改良GPS(MGPS)对结直肠癌肝转移根治性切除术(CRLM)患者预后的评估价值。共有343名患者参加了这项研究。MGPS-0、C反应蛋白≤10 mg/L；MGPS-1、C反应蛋白10 mg/L、白蛋白≥35 mg/L；MGPS-2、C反应蛋白10 mg/L、白蛋白35 mg/L，进行单因素和多因素分析。在343名患者中，295名(86.0%)被分配到MGPS-0，33名(9.6%)被分配到MGPS-1，15名(4.4%)被分配到MGPS-2。MGPS-0、-1和-2患者的中位无病生存期分别为18.3、15.5和5.2个月。MGPS-0、-1和-2患者的中位癌症特异性生存(CSS)分别为89.5个月、62.2个月和25.8个月。MGPS-0患者的CSS明显长于MGPS-2患者。多变量分析显示，癌症相关的术后死亡率与MGP和癌胚抗原水平显著相关。对于接受根治性切除的CRLM患者来说，术前MGPS是一个有用的预后因素。
The inflammation-based Glasgow prognostic score (GPS) has been demonstrated to be prognostic for various tumors. We investigated the value of the modified GPS (mGPS) for the prognosis of patients undergoing curative resection for colorectal liver metastases (CRLM). A total of 343 patients were enrolled onto this study. The mGPS was calculated as follows: mGPS-0, C-reactive protein (CRP) ≤10 mg/L; mGPS-1, CRP >10 mg/L and albumin ≥35 g/L; and mGPS-2, CRP >10 mg/L and albumin <35 g/L. Prognostic significance was retrospectively analyzed by univariate and multivariate analyses. Of the 343 patients, 295 (86.0 %) were assigned to mGPS-0, 33 (9.6 %) to mGPS-1, and 15 (4.4 %) to mGPS-2. The median disease-free survival of patients with mGPS-0, -1, and -2 was 18.3, 15.5, and 5.2 months, respectively. The median cancer-specific survival (CSS) of patients with mGPS-0, -1, and -2 was 89.5, 62.2, and 25.8 months, respectively. The CSS of patients with mGPS-0 was significantly longer than that of patients with mGPS-2. Multivariate analysis revealed a significant association between cancer-related postoperative mortality and mGPS and carcinoembryonic antigen level. The preoperative mGPS is a useful prognostic factor for postoperative survival in patients undergoing curative resection for CRLM.
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影响因子：
9
作者：
Fong, Y;Fortner, J;Blumgart, LH
通讯作者：
Blumgart, LH
影响因子：
9
作者：
Ishizuka, Mitsuru;Nagata, Hitoshi;Kubota, Keiichi
通讯作者：
Kubota, Keiichi
影响因子：
8.8
作者：
Fondevila, C;Metges, J P;Fuster, J;Grau, J J;Palacin, A;Castells, A;Volant, A;Pera, M
通讯作者：
Pera, M
影响因子：
2.7
作者：
Kobayashi, Takashi;Teruya, Masanori;Morita, Koji
通讯作者：
Morita, Koji
影响因子：
9
作者：
de Haas, Robbert J.;Wicherts, Dennis A.;Adam, Rene
通讯作者：
Adam, Rene