Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery.
Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery.
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作者：
Ashitate Y;Hyun H;Kim SH;Lee JH;Henary M;Frangioni JV;Choi HS
切除原发肿瘤的区域淋巴结在外科肿瘤学中是至关重要的。虽然前哨淋巴结定位现在是乳腺癌和黑色素瘤的标准治疗方法，但超过20%的患者需要完成淋巴结切除术。然而，目前还没有技术可以实时成像体内所有淋巴结，或者同时评估前哨淋巴结和所有淋巴结。在这项研究中，我们报道了一种光学荧光技术，能够同时绘制同一受试者的pan淋巴结（pln）和sentinel淋巴结（sln）。我们开发了近红外荧光团，其荧光发射最大值在700 nm或800 nm处。一种是静脉注射，用于识别盆地内所有区域淋巴结，另一种是局部注射，用于识别SLN。采用双通道FLARE术中成像系统，我们可以同时识别和切除所有pln和sln。我们描述的技术可以同时，实时地可视化同一主题的pln和sln。
The resection of regional lymph nodes in the basin of a primary tumor is of paramount importance in surgical oncology. Although sentinel lymph node mapping is now the standard of care in breast cancer and melanoma, over 20% of patients require a completion lymphadenectomy. Yet, there is currently no technology available that can image all lymph nodes in the body in real time, or assess both the sentinel node and all nodes simultaneously. In this study, we report an optical fluorescence technology that is capable of simultaneous mapping of pan lymph nodes (PLNs) and sentinel lymph nodes (SLNs) in the same subject. We developed near-infrared fluorophores, which have fluorescence emission maxima either at 700 nm or at 800 nm. One was injected intravenously for identification of all regional lymph nodes in a basin, and the other was injected locally for identification of the SLN. Using the dual-channel FLARE intraoperative imaging system, we could identify and resect all PLNs and SLNs simultaneously. The technology we describe enables simultaneous, real-time visualization of both PLNs and SLNs in the same subject.
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影响因子：
2.5
作者：
Schaafsma, Boudewijn E.;Mieog, J. Sven D.;Hutteman, Merlijn;Van der Vorst, Joost R.;Kuppen, Peter J. K.;Lowik, Clemens W. G. M.;Frangioni, John V.;Van de Velde, Cornelis J. H.;Vahrmeijer, Alexander L.
通讯作者：
Vahrmeijer, Alexander L.
影响因子：
6
作者：
Ashitate, Yoshitomo;Tanaka, Eiichi;Stockdale, Alan;Choi, Hak Soo;Frangioni, John V.
通讯作者：
Frangioni, John V.
影响因子：
3.7
作者：
Hutteman M;Choi HS;Mieog JS;van der Vorst JR;Ashitate Y;Kuppen PJ;van Groningen MC;Löwik CW;Smit VT;van de Velde CJ;Frangioni JV;Vahrmeijer AL
通讯作者：
Vahrmeijer AL
影响因子：
2.8
作者：
Nakayama, Akira;Bianco, Antonio C;Frangioni, John V
通讯作者：
Frangioni, John V
影响因子：
46.9
作者：
Kim, S;Lim, YT;Frangioni, JV
通讯作者：
Frangioni, JV