Increased Time in Range and Fewer Missed Bolus Injections After Introduction of a Smart Connected Insulin Pen.
Increased Time in Range and Fewer Missed Bolus Injections After Introduction of a Smart Connected Insulin Pen.
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引入智能连接的胰岛素笔之后，范围内的时间增加了，错过的注射量很少。
DOI：
10.1089/dia.2019.0411
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发表时间：
2020-10
影响因子：
5.4
通讯作者：
Hellman J
中科院分区：
文献类型：
--
作者：
Adolfsson P;Hartvig NV;Kaas A;Møller JB;Hellman J
背景：本观察性研究调查了在现实世界中，通过基础胰岛素方案和连续血糖监测，连接的NovoPen®6是否会影响1型糖尿病（T1D）患者的胰岛素方案管理和血糖控制。方法：来自12个瑞典糖尿病诊所的参与者在每次就诊时下载笔数据（最终队列：n = 94）。结果包括范围时间（TIR；传感器葡萄糖3.9 - 10.0 mmol/L）、高血糖时间（>10 mmol/L）和低血糖时间（L1: 3.0 - <3.9 mmol/L; L2: <3.0 mmol/L）。错过丸剂量（MBD）注射是指从用餐开始- 15和+60分钟内没有丸注射的用餐。比较基线期和随访期的结果（≥5次卫生保健专业人员就诊）。每次就诊后的前14天对数据进行分析。对于TIR和总胰岛素剂量分析（n = 94），使用线性混合模型，对于MBD分析（n = 81），使用混合泊松模型。结果：从基线到随访期间，TIR显著增加（+1.9 [0.8;3.0]95% CI h/day, P < 0.001），高血糖发生时间相应减少（- 1.8 [- 3.0;- 0.6]95% CI h/day, P = 0.003）， L2低血糖发生时间相应减少（- 0.3 [- 0.6;- 0.1]95% CI h/day, P = 0.005）， L1低血糖发生时间无变化。MBD注射在研究期间减少了43% （P = 0.002）。在假设参与者每天吃三顿正餐的情况下，MBD注射的变化对应于从25%下降到14%。结论：我们的研究强调了当来自连接笔的可靠胰岛素剂量数据有助于T1D患者胰岛素管理时，对血糖控制和给药行为的潜在益处。
Background: This observational study investigated whether the connected NovoPen® 6 could influence insulin regimen management and glycemic control in people with type 1 diabetes (T1D) using a basal-bolus insulin regimen and continuous glucose monitoring in a real-world setting. Methods: Participants from 12 Swedish diabetes clinics downloaded pen data at each visit (final cohort: n = 94). Outcomes included time in range (TIR; sensor glucose 3.9–10.0 mmol/L), time in hyperglycemia (>10 mmol/L), and hypoglycemia (L1: 3.0– <3.9 mmol/L; L2: <3.0 mmol/L). Missed bolus dose (MBD) injections were meals without bolus injection within −15 and +60 min from the start of a meal. Outcomes were compared between the baseline and follow-up periods (≥5 health care professional visits). Data were analyzed from the first 14 days following each visit. For the TIR and total insulin dose analyses (n = 94), a linear mixed model was used, and for the MBD analysis (n = 81), a mixed Poisson model was used. Results: TIR significantly increased (+1.9 [0.8; 3.0]95% CI h/day; P < 0.001) from baseline to follow-up period, with a corresponding reduction in time in hyperglycemia (−1.8 [−3.0; −0.6]95% CI h/day; P = 0.003) and L2 hypoglycemia (−0.3 [−0.6; −0.1]95% CI h/day; P = 0.005), and no change in time in L1 hypoglycemia. MBD injections decreased by 43% over the study (P = 0.002). Change in MBD injections corresponded to a decrease from 25% to 14% based on the assumption that participants had three main meals per day. Conclusions: Our study highlights the potential benefit on glycemic control and dosing behavior when reliable insulin dose data from a connected pen contribute to insulin management in people with T1D.
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影响因子：
5.4
作者：
Dandona P
通讯作者：
Dandona P
影响因子：
16.2
作者：
Danne T;Nimri R;Battelino T;Bergenstal RM;Close KL;DeVries JH;Garg S;Heinemann L;Hirsch I;Amiel SA;Beck R;Bosi E;Buckingham B;Cobelli C;Dassau E;Doyle FJ 3rd;Heller S;Hovorka R;Jia W;Jones T;Kordonouri O;Kovatchev B;Kowalski A;Laffel L;Maahs D;Murphy HR;Nørgaard K;Parkin CG;Renard E;Saboo B;Scharf M;Tamborlane WV;Weinzimer SA;Phillip M
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Phillip M
影响因子：
120.7
作者：
Lind, Marcus;Polonsky, William;Hellman, Jarl
通讯作者：
Hellman, Jarl
影响因子：
5
作者：
Beck, Roy W;Bergenstal, Richard M;Rodbard, David
通讯作者：
Rodbard, David
影响因子：
6.6
作者：
Bailey, Timothy S.;Stone, Jenine Y.
通讯作者：
Stone, Jenine Y.