hnRNP-U enhances the expression of specific genes by stabilizing mRNA.
hnRNP-U enhances the expression of specific genes by stabilizing mRNA.
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DOI：
10.1016/j.febslet.2006.11.062
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发表时间：
2007-01-09
期刊：
影响因子：
3.5
通讯作者：
Handa H
中科院分区：
文献类型：
--
作者：
Yugami M;Kabe Y;Yamaguchi Y;Wada T;Handa H
异质核核糖核蛋白（hnRNP）被认为参与前mRNA加工。hnRNP-U，也称为支架附着因子A（SAF-A），与前mRNA和核基质/支架附着区DNA元件结合。然而，其在基因表达调控中的作用还知之甚少。在本研究中，我们发现hnRNP-U特异性地增强肿瘤坏死因子α mRNA的表达，可能是通过与3′非翻译区结合来增加其稳定性。我们还发现，hnRNP-U通过结合和稳定这些mRNA，也增强了其他几个基因的表达，包括GADD 45 A，HEXIM 1，HOXA 2，IER 3，NHLH 2和ZFY。这些结果表明，hnRNP-U通过调节mRNA的稳定性来增强特定基因的表达。
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-mRNA processing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre-mRNA and nuclear matrix/scaffold attachment region DNA elements. However, its role in the regulation of gene expression is as yet poorly understood. In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor α mRNA by increasing its stability, possibly through binding to the 3′ untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. These results suggest that hnRNP-U enhances the expression of specific genes by regulating mRNA stability.
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