Contextual influences on subjective alcohol response.

Contextual influences on subjective alcohol response.
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DOI:
10.1037/pha0000415
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发表时间:
2021-03
影响因子:
2.3
通讯作者:
Fromme K
Fromme K
中科院分区:
医学3区
文献类型:
--
作者:
Corbin WR;Hartman JD;Bruening AB;Fromme K

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先前的研究表明,环境对动物和人类的药物反应有影响,尽管人类的研究通常只关注环境的一个方面(例如,社会),并检查有限范围的主观经验。目前的研究试图通过研究社会和物理环境对主观酒精影响的影响来解决这些限制。样本包括448名年轻成年社交饮酒者(57%男性,66.5%白色),随机分配到四种环境(单独实验室,组实验室,单独酒吧,组酒吧)之一的酒精(目标血液酒精浓度(BAC)为0.08 g%)或安慰剂。结果表明,酒精的高唤醒积极(HAP)效应(例如,健谈,活泼)在非酒吧环境中相对于酒吧环境更强,且低唤醒积极效果(例如,放松,平静)只存在于小组实验室的背景下。也有社会背景的主要影响,如高唤醒效果(积极和消极)更强的群体背景下,无论饮料条件。这些发现强调了在研究酒精影响时考虑背景的重要性。旨在分离药理学HAP效应的研究可能会受益于非酒吧环境,而在模拟起居室或家庭环境中对HAP效应的研究可能最有效,尽管需要未来的研究来直接解决这种可能性。此外,明确关注期望或需要对期望进行强有力控制的研究可能会受益于群体背景,特别是在研究高唤醒效应时。
Prior research demonstrates contextual influences on drug responses in both animals and humans, though studies in humans typically focus on only one aspect of context (e.g., social), and examine a limited range of subjective experiences. The current study sought to address these limitations by examining the impact of both social and physical context on the full range of subjective alcohol effects. The sample included 448 young adult social drinkers (57% male, 66.5% White) randomly assigned to consume alcohol (target blood alcohol concentration (BAC) of .08 g%) or placebo in one of four contexts (solitary lab, group lab, solitary bar, group bar). Results indicated that high arousal positive (HAP) effects of alcohol (e.g., talkative, lively) were stronger in non-bar relative to bar contexts, and that low arousal positive effects (e.g., relaxed, calm) were only present in the group lab context. There were also main effects of social context such that high arousal effects (both positive and negative) were stronger in group contexts, regardless of beverage condition. These findings highlight the importance of considering context when examining alcohol effects. Studies designed to isolate pharmacological HAP effects may benefit from a non-bar setting, and studies of LAP effects might be most effective in a simulated living room or home environment, though future studies are needed to directly address this possibility. Further, studies with an explicit focus on expectancies or that need strong control for expectancies might benefit from a group context, particularly when studying high arousal effects.
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