Metchnikoff's policemen: macrophages in development, homeostasis and regeneration.
Metchnikoff's policemen: macrophages in development, homeostasis and regeneration.
复制标题
DOI：
10.1016/j.molmed.2011.07.009
复制
发表时间：
2011-12
影响因子：
13.6
通讯作者：
Duffield JS
中科院分区：
文献类型：
--
作者：
Stefater JA 3rd;Ren S;Lang RA;Duffield JS
在过去的十年中，现代遗传工具使科学家能够前所未有地研究包括巨噬细胞在内的髓系细胞的功能。巨噬细胞在世纪前首次被发现是摄取细菌和其他微生物的细胞，但现在人们知道它们的功能作用要多得多。在这篇综述中，我们专注于在先天免疫的作用以外的巨噬细胞的主要功能。我们强调巨噬细胞作为发展，组织稳态，重塑（现有组织的重组或翻新）和修复的调节器的例子。我们还详细介绍了现代遗传工具如何促进对这些神秘细胞的新见解。
Over the past decade, modern genetic tools have permitted scientists to study the function of myeloid lineage cells, including macrophages, as never before. Macrophages were first detected more than a century ago as cells that ingested bacteria and other microbes, but it is now known that their functional roles are far more numerous. In this review, we focus on the prevailing functions of macrophages beyond their role in innate immunity. We highlight examples of macrophages acting as regulators of development, tissue homoeostasis, remodeling (the reorganization or renovation of existing tissues), and repair. We also detail how modern genetic tools have facilitated new insights into these mysterious cells.
登录
查看更多内容
影响因子：
3.6
作者：
BRANNSTROM, M;MAYRHOFER, G;ROBERTSON, SA
通讯作者：
ROBERTSON, SA
影响因子：
20.3
作者：
Gordy, Claire;Pua, Heather;He, You-Wen
通讯作者：
He, You-Wen
影响因子：
20.3
作者：
Fantin, Alessandro;Vieira, Joaquim M.;Ruhrberg, Christiana
通讯作者：
Ruhrberg, Christiana
影响因子：
--
作者：
Gouon-Evans, V;Pollard, JW
通讯作者：
Pollard, JW
影响因子：
15.9
作者：
Duffield, JS;Forbes, SJ;Iredale, JP
通讯作者：
Iredale, JP