Encoding and consolidation of motor sequence learning in young and older adults.
Encoding and consolidation of motor sequence learning in young and older adults.
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DOI：
10.1016/j.nlm.2021.107508
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发表时间：
2021-11
影响因子：
2.7
通讯作者：
Spencer RMC
中科院分区：
文献类型：
--
作者：
Fitzroy AB;Kainec KA;Seo J;Spencer RMC
睡眠有利于年轻人的运动记忆巩固，但这种好处在老年人中减少。在这里，我们试图了解年轻人和老年人之间的编码的神经基础的差异是否有助于与年龄相关的差异，睡眠依赖性巩固的一个明确的变体的系列反应时间任务（SRTT）。17名年轻人和18名老年人完成了两次会议（午睡，醒来），间隔一周。在MRI中，参与者学习了SRTT。在清醒或午睡的下午间隔（用高密度多导睡眠图记录）后，在MRI中重新评估SRTT的表现。SRTT表现的成像和行为结果显示，与等间隔清醒相比，老年人白天小睡后运动序列学习的睡眠依赖性巩固明显。然而，年轻人在编码过程中表现出与睡眠间隔前的高SRTT表现一致的大脑活动和行为，并且没有表现出进一步的睡眠依赖性表现改善。年轻人在睡眠后确实表现出皮质活动减少，这表明与自动化相关的潜在系统水平巩固。睡眠生理学数据表明，sigma活动地形图的影响，海马和皮层激活之前，午睡在两个年龄组，并建议在年轻人的睡眠依赖性自动化的作用θ活动。这些结果表明，以前观察到的与年龄相关的睡眠依赖性巩固缺陷可能是由快速学习过程中与年龄相关的缺陷驱动的。在这里，我们证明，当足够的编码强度达到额外的培训，老年人表现出完整的睡眠依赖巩固运动序列学习。
Sleep benefits motor memory consolidation in young adults, but this benefit is reduced in older adults. Here we sought to understand whether differences in the neural bases of encoding between young and older adults contribute to aging-related differences in sleep-dependent consolidation of an explicit variant of the serial reaction time task (SRTT). Seventeen young and 18 older adults completed two sessions (nap, wake) one week apart. In the MRI, participants learned the SRTT. Following an afternoon interval either awake or with a nap (recorded with high-density polysomnography), performance on the SRTT was reassessed in the MRI. Imaging and behavioral results from SRTT performance showed clear sleep-dependent consolidation of motor sequence learning in older adults after a daytime nap, compared to an equal interval awake. Young adults, however, showed brain activity and behavior during encoding consistent with high SRTT performance prior to the sleep interval, and did not show further sleep-dependent performance improvements. Young adults did show reduced cortical activity following sleep, suggesting potential systems-level consolidation related to automatization. Sleep physiology data showed that sigma activity topography was affected by hippocampal and cortical activation prior to the nap in both age groups, and suggested a role of theta activity in sleep-dependent automatization in young adults. These results suggest that previously observed aging-related sleep-dependent consolidation deficits may be driven by aging-related deficiencies in fast learning processes. Here we demonstrate that when sufficient encoding strength is reached with additional training, older adults demonstrate intact sleep-dependent consolidation of motor sequence learning.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
5.3
作者：
Axmacher, Nikolai;Mormann, Florian;Fell, Juergen
通讯作者：
Fell, Juergen
影响因子：
5.7
作者：
Albouy, Genevieve;Fogel, Stuart;Doyon, Julien
通讯作者：
Doyon, Julien
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF