Activation of hedgehog signaling is not a frequent event in ovarian cancers.
Activation of hedgehog signaling is not a frequent event in ovarian cancers.
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刺猬信号的激活在卵巢癌中并不常见
DOI：
10.1186/1476-4598-8-112
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发表时间：
2009-11-27
期刊：
影响因子：
37.3
通讯作者：
Xie J
中科院分区：
文献类型：
--
作者：
Yang L;He J;Huang S;Zhang X;Bian Y;He N;Zhang H;Xie J
刺猬（Hh）信号通路调节许多发育和组织稳态的过程。据报道，hedgehog信号的激活在约30%的人类癌症中，包括卵巢癌。抑制hedgehog信号传导已被作为癌症治疗的有效策略，包括正在进行的卵巢癌II期临床试验。然而，不同的研究组报告的卵巢癌中hedgehog信号激活的速率不同。为了预测hedgehog信号抑制剂在卵巢癌中的临床试验的成功，我们通过原位杂交、免疫组织化学、RT-PCR和实时PCR分析了34例卵巢上皮性肿瘤标本中hedgehog信号通路的激活。与以前的报道相反，我们只检测到一小部分卵巢癌hedgehog靶基因表达，这表明识别具有激活的hedgehog信号传导激活的肿瘤将有助于用hedgehog信号传导抑制剂进行化疗。
The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer. Inhibition of hedgehog signaling has been pursued as an effective strategy for cancer treatment including an ongoing phase II clinical trial in ovarian cancer. However, the rate of hedgehog signaling activation in ovarian cancer was reported differently by different groups. To predict the successful for future clinical trials of hedgehog signaling inhibitors in ovarian cancer, we assessed hedgehog pathway activation in 34 ovarian epithelial tumor specimens through analyses of target gene expression byin-situhybridization, immunohistochemistry, RT-PCR and real-time PCR. In contrast to previous reports, we only detected a small proportion of ovarian cancers with hedgehog target gene expression, suggesting that identification of the tumors with activated hedgehog signaling activation will facilitate chemotherapy with hedgehog signaling inhibitors.
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